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BCR — TMED7

Text-mined interactions from Literome

Gesbert et al., J Biol Chem 2000 : We demonstrate that the decrease of p27 ( Kip1 ) is directly due to BCR/ABL in hematopoietic cells by two different approaches ... The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27 ( Kip1 ) down-regulation and inhibits BCR/ABL induced entry into S phase ... Overall, these data are consistent with a model in which BCR/ABL suppresses p27 ( Kip1 ) protein levels through PI3K/AKT, leading to accelerated entry into S phase
Banerji et al., Oncogene 2001 (Lymphoma, B-Cell...) : We show that BCR stimulation of WEHI 231 cells results in down-regulation of cyclin D2 and up-regulation of p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation
Fan et al., Chin Med J (Engl) 2001 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In this model, we showed that the presence of p210BCR/ABL leads to elevated levels of p27kip in p210BCR/ABL expressing CD34+ cells
Schuster et al., Blood 2003 : In contrast, the up-regulation of PU.1 and p27 ( Kip1 ) by G-CSF was not affected by Bcr-Abl
Andreu et al., Cancer Res 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We further show that BCR-ABL also regulates p27 ( Kip1 ) protein levels by increasing its degradation by the proteasome ... In conclusion, these results suggest that BCR-ABL regulates cell cycle in CML cells at least in part by inducing proteasome mediated degradation of the cell cycle inhibitor p27 ( Kip1 ) and provide a rationale for the use of inhibitors of the proteasome in patients with BCR-ABL leukemias
Rangatia et al., Leukemia 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Lack of BCR-ABL leads to cell cycle arrest in G1 phase as observed by decrease in cyclin D1 and increase in p21 and p27 cdk inhibitors mRNA
Craxton et al., Eur J Immunol 2007 : Likewise, BCR induced p27 ( Kip1 ) degradation was decreased in Bim KO compared to WT B cells
Richards et al., Eur J Immunol 2009 : BCR ligation leads to a more rapid decrease in p27 ( Kip1 ) levels in gp91(phox) KO B cells