Mohri et al., Int J Cancer 2009
(Neoplasms) :
1,25 ( OH ) ( 2 ) D ( 3 ) drastically induced the CYP24 mRNA level in MCF-7 cells, but the induction was markedly attenuated by the overexpression of miR-125b Komagata et al., Mol Pharmacol 2009
(Breast Neoplasms) :
Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b ... We investigated whether CYP24 is regulated by miR-125b ... These results suggested that human CYP24 is regulated by miR-125b ... In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24 , which serves as a possible mechanism for the high CYP24 expression in cancer tissues