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LDLR — LPA
Text-mined interactions from Literome
Snyder et al., J Biol Chem 1992
:
At 4 degrees C,
LDL receptor mediated binding of both
Lp(a) and LDL was of low affinity, being 0.8 and 0.23 microM, respectively
Zawadzki et al., Biochemistry 1988
:
Accordingly, the binding of the lipoproteins to the
LDL receptor was also decreased in the
presence of
apo(a)
Snyder et al., Arterioscler Thromb 1994
:
LDL receptor mediated degradation of 50 nmol/L
Lp(a) in hepatocytes, macrophages, and fibroblasts was only 17 %, 22 %, and 26 %, respectively, of the value obtained with 50 nmol/L LDL and varied greatly among the cells in that it was lowest in hepatocytes, an order of magnitude greater in macrophages, and two orders of magnitude greater in fibroblasts ... Additionally, they show that there are great cellular differences in the
LDL receptor mediated degradation of
Lp(a) ... If these results can be extrapolated in vivo, where normal LDL levels are 40- to 50-fold higher than those of Lp(a), it would be unlikely that the hepatic
LDL receptor is significantly
involved in the degradation of
Lp(a)
Schmidt et al., Blood Coagul Fibrinolysis 1993
(Coronary Disease...) :
The effect of the cholesterol synthesis inhibitor on
Lp(a) may be
due to the upregulation of the
LDL-receptor , suggesting a role for LDL receptor in Lp(a) catabolism