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EGF — SOS1

Pathways - manually collected, often from reviews:

• BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy: EGF/EGF R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta keratinocyte differentiation: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → mTOR (MTOR) (modification, activates) Iwasaki et al., Endocrinology 1999
  Evidence: mutant phenotype, other species
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
  Evidence: assay
• NCI Pathway Database ErbB1 downstream signaling: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → SOS1 (SOS1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → Eps8/ABI1/SOS1 complex (EPS8-ABI1-SOS1) (modification, activates)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: None → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: HRAS/GDP complex (HRAS) → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database Internalization of ErbB1: GRB2 (GRB2) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → EGF (EGF) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → EGFR (EGFR) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → SOS1 (SOS1) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGF (EGF) → SOS1 (SOS1) (modification, collaborate) Burke et al., Mol Biol Cell 2001
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: Vps24 (CHMP3) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (translocation, activates)
  Burke et al., Mol Biol Cell 2001, Ravid et al., J Biol Chem 2004, Mosesson et al., Dev Cell 2009, Levkowitz et al., Genes Dev 1998
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• Reactome Reaction: EGF → SOS1 (reaction) Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995
• Reactome Reaction: EGF → SOS1 (indirect_complex) Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995

Text-mined interactions from Literome

Akamatsu et al., J Biol Chem 1999 : Phosphatase treatment of lysates restored the binding of Sos to vinexin, suggesting that signaling from serum, EGF , or PDGF regulates the vinexin-Sos complex through the Sos phosphorylation
Take et al., Biochem Biophys Res Commun 2000 : Our results suggest that CIN85 may play a specific role in the EGF receptor mediated signaling cascade via its interaction with c-Cbl
Kowanetz et al., J Biol Chem 2003 : Identification of a novel proline-arginine motif involved in CIN85 dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
Oh-hora et al., J Exp Med 2003 : The BCR requires RasGRP3 ; in contrast, epidermal growth factor receptor is dependent on Sos1 and Sos2
Zhao et al., Nat Cell Biol 2007 : This interaction is essential for epidermal growth factor (EGF) induced Sos membrane recruitment and Ras activation
Medema et al., Mol Cell Biol 1994 : Calcium treatment, however, did not interfere with EGF induced EGF receptor autophosphorylation or association of mammalian SOS with the EGF receptor and Shc
Basu et al., Oncogene 1994 : The binding of Sos to tyrosine phosphorylated receptor, via Grb2 may also contribute to Ras activation by EGF but not NGF, while stable complex formation between Shc and receptors is not necessary for Ras activation by either growth factor
Welham et al., J Biol Chem 1994 : In addition, we did not observe significant epidermal growth factor induced translocation of Sos1 to the membrane in Rat-1 cells
Holt et al., J Biol Chem 1996 : Although EGF stimulation of the mutant EGF receptor activates ERK and phosphorylation of both Shc and SOS , it fails to directly associate with either Shc or Grb2
Douville et al., Oncogene 1997 : EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2
Ishiki et al., Endocrinology 1997 : Neither insulin nor EGF treatment induced Crk-II association with either Sos or C3G
Kavanagh et al., Radiat Res 1998 : In contrast, EGF activated SOS as shown by the enhanced association of SOS with EGFR in co-immunoprecipitation experiments