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RAC1 — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RAC1 → TLR2 (increases, TLR2 Activity, RAC1 Activity) Arbibe et al., Nat Immunol 2000*
  Evidence: Modified assertion
• KEGG Toll-like receptor signaling pathway: TLR2 → RAC1 (protein-protein, activation)
• WikiPathways Regulation of toll-like receptor signaling pathway: TLR2 → RAC1 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: TLR2 → RAC1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TLR2 — RAC1 (in vivo) Arbibe et al., Nat Immunol 2000*

Text-mined interactions from Literome

Shen et al., Infect Immun 2010 (Listeriosis) : Moreover, functional activation of PI3K and Rac1 was impaired in TLR2 ( -/- ) and MyD88 ( -/- ) macrophages
West et al., Nature 2010 (Inflammation...) : Both TLR2 and MyD88 are required for CEP induced stimulation of Rac1 and endothelial migration
Wen et al., J Exp Med 2010 (Peritonitis...) : Plexin-A4 is required for TLR induced activation of the small guanosine triphosphate hydrolase ( GTPase ) Rac1 ( ras related C3 botulinum toxin substrate 1 )
Jiang et al., PloS one 2012 (Uveitis) : The synergistic effect of TLR2 and NOD2 ligands on RAC activation might be explained by the observations that bacterial lipoprotein ( BLP, a TLR2 ligand ) was able to upregulate NOD2 expression and the combination of BLP and muramyldipeptide ( MDP, a NOD2 ligand ) enhanced the expression of RICK ( Rip2 ), the signaling molecule of NOD2