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NOX3 — PIK3CA
Text-mined interactions from Literome
Yamamori et al., Biochem Biophys Res Commun 2004
:
Pharmacological inhibition of
PI3K attenuated both fMLP stimulated p47(phox) phosphorylation and
NADPH oxidase activity in HL-60 cells differentiated to a neutrophil-like phenotype
Min et al., J Immunol 2005
:
It also led to the production of reactive oxygen species via PKC- and
PI3K dependent activation of
NADPH oxidase in the endothelial cells, and antioxidants suppressed the responses to TRANCE
Bréchard et al., J Leukoc Biol 2009
:
In contrast to SOCE inhibition, OAG induced
NOX2 activation was
mediated by PKC and
PI3K
Xia et al., Journal of thrombosis and haemostasis : JTH 2010
:
Protein kinase Czeta mediates
PI3K regulated
NADPH oxidase activation by promoting cellular p47phox translocation
Yang et al., Eur J Pharmacol 2010
:
These results suggest that plumbagin activates
NAD ( P ) H oxidase , Src, and PI3K, and that the activated
PI3K or PDK1 subsequently
stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
Andrographolide inhibits
PI3K/AKT dependent
NOX2 and iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Jin et al., Stroke 2011
(Infarction, Middle Cerebral Artery...) :
PI3K? deficiency
suppressed ischemia/reperfusion induced nuclear factor-?B p65 ( Ser536 ) phosphorylation and the expression of the pro-oxidant enzyme
NADPH oxidase ( Nox1, Nox2, and Nox4 ) and proinflammatory adhesion molecules ( E- and P-selectin, intercellular adhesion molecule-1 ) at different time points
Chatterjee et al., Am J Physiol Heart Circ Physiol 2012
(Ischemia) :
Activation of
NOX2 was greatly
diminished by wortmannin, knockout of Akt1, or dominant negative
PI3K , whereas membrane depolarization was unaffected
Huang et al., Free Radic Biol Med 2012
(Carcinoma...) :
Accordingly, we suggest that
PI3K/AKT signaling
mediates TGIF induced
Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2012
(Colonic Neoplasms) :
These responses are related to intracellular reactive oxygen species ( ROS ) generation,
NADPH oxidase activation , and upregulation of
PI3K/Akt and hypoxia-inducible factor 1 alpha ( HIF-1a ) signaling
Brennan-Minnella et al., Cell death & disease 2013
:
The
PI3K inhibitor wortmannin
prevented NMDA induced
NOX2 activation and cell death, without preventing cell swelling, calcium elevation, or mitochondrial depolarization