Gene interactions and pathways from curated databases and text-mining

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IGF1 — TRH

Text-mined interactions from Literome

Murietta-Geoffroy et al., Horm Metab Res 1990 : The effects of TRH on insulin-like growth factor I receptors were investigated on erythrocytes from 7 GH-deficient children having plasma GH levels less than 10 ng/ml during two provocation tests
Blanchard et al., Reprod Nutr Dev 1987 : these data indicate that in prepubertal male lambs : the stimulatory effect of GRF is predominant over the inhibitory effect of SRIF, somatostatin inhibits TRH stimulation of GH secretion in vitro, and IGF-I may control GH secretion by modulating GRF effects at the pituitary level
Buonomo et al., Gen Comp Endocrinol 1987 : Effects of insulin-like growth factor I (IGF-I) on growth hormone releasing factor (GRF) and thyrotropin releasing hormone (TRH) stimulation of growth hormone (GH) secretion in the domestic fowl ( Gallus domesticus )
Bucher et al., N Engl J Med 1983 (Body Weight...) : Seven patients with excessive growth ( Group A ) had hyperinsulinism, normal IGF values, elevated basal prolactin levels, and a delayed thyrotropin response to thyrotropin releasing hormone , which was compatible with hypothalamic lesions
Yamada et al., Endocr J 1997 (Acromegaly...) : Therefore, 34 ( 87.1 % ) out of 39 patients who have been followed up longer than 6 months met the following stringent criteria at the time of the final follow-up : mean basal GH level < 3 ng/ml, a normal IGF-1 level, and normal GH response to TRH , GnRH and oral glucose administration
Selvais et al., Eur J Endocrinol 1998 (Adenoma...) : Plasma IGF-I concentration and the TSH peak response to TRH were significantly lower in patients with macroadenoma than in those with microadenoma ( 0.4+/-0.2 x 10 ( 3 ) IU/I and 2.3+/-1.8 mIU/I, compared with 1.8+/-0.6 x 10 ( 3 ) IU/I and 5.2+/-1.6 mUI/l ; P < 0.05 )