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BCL2 — IGF1
Text-mined interactions from Literome
Pugazhenthi et al., J Biol Chem 1999
:
Thus, we have characterized a novel signaling pathway ( MAPK kinase 6/p38beta MAPK/MAPKAP-K3 ) that defines a transcriptional mechanism for the
induction of the antiapoptotic protein
Bcl-2 by
IGF-I through the nuclear transcription factor cAMP-response element binding protein in PC12 cells
Fornoni et al., Am J Pathol 2001
:
We investigated whether
Bcl-xL and Fas/Fas-ligand were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was
prevented by HGF or
IGF-I ... HGF, but not
IGF-I , prevented apoptosis and
restored Bcl-xL levels
Yamamura et al., Am J Physiol Heart Circ Physiol 2001
(Myocardial Reperfusion Injury) :
IGF-I differentially
regulates Bcl-xL and Bax and confers myocardial protection in the rat heart ... The present study examined the
effect of
IGF-I on the expression of
Bcl-2 family proteins in the rat heart mitochondria in relation to myocardial protection against ischemia-reperfusion injury ... These results suggest that
IGF-1 differentially
regulates Bcl-xL and Bax in heart mitochondria, which may be causally related to myocardial protection against ischemia-reperfusion injury
Chrysis et al., J Neurosci 2001
(Nervous System Malformations) :
IGF-I decreases caspase-3 availability and activity,
increases the expression of anti-apoptotic Bcl-x ( L ) and
Bcl-2 during early postnatal development, and decreases proapoptotic Bax and Bad expression at later developmental stages
Nakao et al., J Thorac Cardiovasc Surg 2001
(Disease Models, Animal...) :
Immunohistochemical studies revealed that
insulin-like growth factor 1 increased expression of the antiapoptotic
Bcl-xL protein and inhibited expression of the proapoptotic Bax protein in motor neuron cells 24 and 48 hours after the operation
Gao et al., J Clin Endocrinol Metab 2001
(Leiomyoma...) :
The present study was conducted to elucidate whether
IGF-I affects apoptosis and
Bcl-2 protein expression, an apoptosis inhibiting gene product, in cultured leiomyoma cells
Beierle et al., J Pediatr Surg 2002
(Neuroblastoma) :
IGF-I protects neuroblastoma cells from apoptosis and
increases Bcl-2 expression
Maruo et al., Steroids 2003
(Leiomyoma...) :
Treatment with P4 augmented EGF and
Bcl-2 protein expression, but
inhibited IGF-I and TNFalpha expression in cultured leiomyoma cells
Kim et al., Mol Reprod Dev 2006
:
In both IVF and SCNT embryos, anti-IGF-IR antibody along with IGF-I neutralized the
effect of
IGF-I on expression of
Bcl-2 and Bax genes
Hung et al., Journal of neurosurgery. Spine 2007
(Disease Models, Animal...) :
Furthermore,
IGF-I attenuated caspase-9 cleavage,
increased Bcl2 , and thus inhibited apoptosis after SCI
Hilmi et al., J Invest Dermatol 2008
(Melanoma) :
Accordingly,
IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family --
BCL2 and BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin ... Accordingly,
IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family --
BCL2 and BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin
Singh et al., Growth Factors 2008
(Breast Neoplasms) :
Furthermore,
IGF-II differentially
regulated the intracellular translocation of
Bcl-2 and Bcl-X ( L ), a critical process in breast cancer progression to hormone-independence
Mani et al., Reproduction 2010
:
IGF1 or FSH alone or both together
had no effect on
BCL2 expression
Chand et al., J Immunol 2012
(Chronic Disease...) :
Intracellular
insulin-like growth factor-1 induces
Bcl-2 expression in airway epithelial cells ... Silencing the IGF-1 expression using short hairpin RNA showed that intracellular
IGF-1 ( IC-IGF-1 ) was
increasing Bcl-2 expression ... These studies demonstrate that
IC-IGF-1 induces
Bcl-2 expression in epithelial cells via IGF-1R and epidermal growth factor receptor pathways, and targeting IC-IGF-1 could be beneficial to treat chronic airway diseases
Chand et al., Am J Respir Cell Mol Biol 2012
(Acute Disease...) :
Suppression of
IGF-1 expression using retroviral shRNA
blocked Bcl-2 expression in human and murine airway epithelial cells and Muc5ac in primary murine airway epithelial cells ... These findings show that acute inflammation
induces IGF-1 to mediate
Bcl-2 and Muc5ac expression in airway epithelial cells
Singleton et al., J Biol Chem 1996
:
Finally, increased neuronal
IGF-IR expression
enhances the negative death regulator
Bcl-xL
Wang et al., Endocrinology 1998
:
To investigate IGF-I actions on apoptosis of H9C2 cardiac muscle cells, we have defined the
effects of
IGF-I on
Bcl-2 , Bax, caspase 3, DNA fragmentation, and cell survival ... Interestingly, there is a compensatory rise in the abundance of Bcl-2 upon serum withdrawal and doxorubicin treatment, and
IGF-I stimulation
resulted in decreased induction of
Bcl-2
Suzuki et al., FEBS Lett 1998
:
It was also found that R-Ras and
IGF-1 cooperatively
induced Bcl-xL expression and inhibited caspase-3 activation