Gene interactions and pathways from curated databases and text-mining

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EGR1 — MAP2K5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Grimes et al., J Neurochem 1999 (Neuroblastoma) : Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells
Maehara et al., FASEB J 2001 : The pathway by which PDGF induced Egr-1 involved the mitogen activated protein kinase kinase-1 ( MEK1 ) and extracellular signal regulated kinases 1 and 2 ( ERK1/2 ), because the effect of PDGF on the induction of Egr-1 was blocked by U0126, a specific MEK1 inhibitor