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TIMP3 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TNF → TIMP3 (increases, TNF Activity)
  Evidence: TIMP-3 expressing stable colon carcinoma cell lines display reduced tumor growth, 199 and in these cells TIMP-3 overexpression resulted in apoptosis through stabilization of TNF-a receptors on the cell surface. 200 This suggests that individual TIMPs may modulate the levels of death proteins from the cell surface, as demonstrated by findings that shedding of FAS from the cell surface is mediated by MMP-induced cleavage and is inhibited by synthetic MMP inhibitors. 201

Text-mined interactions from Literome

Bugno et al., FEBS Lett 1999 : Simultaneously, IL-1beta/TNF alpha almost completely blocks TIMP-3 expression
Lee et al., Biochem Biophys Res Commun 2001 : We previously reported that tumor necrosis factor-alpha converting enzyme ( TACE ) was specifically inhibited by TIMP-3 but not TIMP-1, -2, and -4
Fréour et al., Int J Mol Med 2009 (Inflammatory Bowel Diseases) : TNF-alpha production and the bioavailability of its receptors on the cell surface are regulated by TACE ( TNF-alpha converting enzyme ), a pleiotropic metalloprotease also known as ADAM17, and its specific inhibitor TIMP3
Kassiri et al., J Biol Chem 2009 (Endomyocardial Fibrosis) : We reported that the loss of Timp3 ( tissue inhibitor of metalloproteinase 3 ) leads to abnormal TNF signaling and cardiovascular function
Sun et al., J Biol Chem 1995 : TIMP-3 gene expression was inducible by AP-1 and NF-KB activators, 12-O-tetradecanoylphorbol-13-acetate, and tumor necrosis factor-alpha only in preneoplastic cells with an induction peak at 2 h post-treatment, suggesting classification of mTIMP-3 as a member of the immediate early gene family
Nelimarkka et al., Matrix Biol 1998 : TNF-alpha had no effect on the TIMP-1 and TIMP-2 mRNA levels and did not induce TIMP-3 or TIMP-4 expression
Amour et al., FEBS Lett 1998 : TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3