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CD8B — TNF
Text-mined interactions from Literome
El-Sheikh et al., J Autoimmun 1999
(Diabetes Mellitus, Type 1) :
Depletion of either CD4 ( + ) or
CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and
increasing IL-4 and
TNF-alpha production systemically
Liu et al., Am J Respir Cell Mol Biol 1999
:
Perforin independent
CD8 ( + ) T-cell mediated cytotoxicity of alveolar epithelial cells is preferentially
mediated by
tumor necrosis factor-alpha : relative insensitivity to Fas ligand
Suda et al., J Immunol 1992
:
Of 15 cytokines tested, only transforming growth factor ( TGF-beta ) and
TNF-alpha induced
CD8 ( Lyt-2 ), while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes ... In contrast, neither TGF-beta nor
TNF-alpha induced
CD8 expression on splenic CD4+CD8- T cells
Lang et al., J Clin Invest 2006
(Liver Diseases) :
While TLR3 activation did not directly alter liver-specific
CD8+ T cell function, it
induced IFN-alpha and
TNF-alpha release
Bertolino et al., Hepatology 2007
:
While TLR3 activation did not directly alter liver-specific
CD8+ T cell function, it
induced IFN-alpha and
TNF-alpha release
Singh et al., J Leukoc Biol 2007
(Lymphocytic Choriomeningitis) :
Collectively, these data are strongly suggestive of a
role for
TNF in down regulating
CD8 T cell responses and the establishment of CD8 T cell memory during an acute viral infection
Wong et al., J Immunol 2009
:
IL-12p70 production was produced predominantly by
CD8alpha ( + ) DCs and plasmacytoid DCs, and
mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF,
TNF-alpha , and surface CD40L
Andrade et al., J Acquir Immune Defic Syndr 2010
(Acquired Immunodeficiency Syndrome) :
CD8 ( + ) T lymphocytes depletion
reduced IL-1beta and
TNF-alpha release in the older groups, however, it did not significantly alter their IFN-gamma production
Freeman et al., J Immunol 2010
(Pulmonary Disease, Chronic Obstructive) :
In vitro stimulation of lung
CD8 ( + ) T cells with IL-18 plus IL-12 markedly
increased production of IFN-gamma and
TNF-alpha , whereas IL-15 stimulation induced increased intracellular perforin expression
Ablamunits et al., Eur J Immunol 2010
(Diabetes Mellitus, Type 1) :
The induction of
CD8 ( + ) Treg by anti-CD3 mAb
requires TNF and signaling through the NF-?B cascade
Robinet et al., J Immunol 1990
:
TNF did not
affect the expression of LFA1, CD2, CD4, and
CD8 , molecules that are associated with CTL-target interactions, on responder cells
Soloviova et al., J Immunol 2013
(Graft vs Host Disease) :
A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong
TNF dependent donor antihost
CD8 CTL T cell response