Gene interactions and pathways from curated databases and text-mining

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CD8B — TNF

Text-mined interactions from Literome

El-Sheikh et al., J Autoimmun 1999 (Diabetes Mellitus, Type 1) : Depletion of either CD4 ( + ) or CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and increasing IL-4 and TNF-alpha production systemically
Liu et al., Am J Respir Cell Mol Biol 1999 : Perforin independent CD8 ( + ) T-cell mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha : relative insensitivity to Fas ligand
Suda et al., J Immunol 1992 : Of 15 cytokines tested, only transforming growth factor ( TGF-beta ) and TNF-alpha induced CD8 ( Lyt-2 ), while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes ... In contrast, neither TGF-beta nor TNF-alpha induced CD8 expression on splenic CD4+CD8- T cells
Lang et al., J Clin Invest 2006 (Liver Diseases) : While TLR3 activation did not directly alter liver-specific CD8+ T cell function, it induced IFN-alpha and TNF-alpha release
Bertolino et al., Hepatology 2007 : While TLR3 activation did not directly alter liver-specific CD8+ T cell function, it induced IFN-alpha and TNF-alpha release
Singh et al., J Leukoc Biol 2007 (Lymphocytic Choriomeningitis) : Collectively, these data are strongly suggestive of a role for TNF in down regulating CD8 T cell responses and the establishment of CD8 T cell memory during an acute viral infection
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF, TNF-alpha , and surface CD40L
Andrade et al., J Acquir Immune Defic Syndr 2010 (Acquired Immunodeficiency Syndrome) : CD8 ( + ) T lymphocytes depletion reduced IL-1beta and TNF-alpha release in the older groups, however, it did not significantly alter their IFN-gamma production
Freeman et al., J Immunol 2010 (Pulmonary Disease, Chronic Obstructive) : In vitro stimulation of lung CD8 ( + ) T cells with IL-18 plus IL-12 markedly increased production of IFN-gamma and TNF-alpha , whereas IL-15 stimulation induced increased intracellular perforin expression
Ablamunits et al., Eur J Immunol 2010 (Diabetes Mellitus, Type 1) : The induction of CD8 ( + ) Treg by anti-CD3 mAb requires TNF and signaling through the NF-?B cascade
Robinet et al., J Immunol 1990 : TNF did not affect the expression of LFA1, CD2, CD4, and CD8 , molecules that are associated with CTL-target interactions, on responder cells
Soloviova et al., J Immunol 2013 (Graft vs Host Disease) : A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong TNF dependent donor antihost CD8 CTL T cell response