Foryst-Ludwig et al., J Biol Chem 2000
:
Here we report that in H. pylori infection p21 activated kinase 1 (PAK1) activates NF-kappaB Adams et al., J Nutr 2004
:
Additionally, the use of a p-21 activated kinase ( PAK1 ) inhibitory construct ( PAK ( R299 ) ) demonstrated that PAK1 was also required for NFkappaB transcriptional activation by 1,25 ( OH ) ( 2 ) D ( 3 )
Tseng et al., Am J Physiol Cell Physiol 2006
(Inflammation) :
Apical Pseudomonas aeruginosa strain PAK ( but not flagellin mutant PAK.fliC ), flagellin, and flagellin + PAK.fliC activated NF-kappaB and IL-8 expression and secretion
Orr et al., Circ Res 2008
:
We now show that inhibiting PAK in cells on fibronectin blocked NF-kappaB activation by both laminar and oscillatory flow in vitro and at sites of disturbed flow in vivo ... These data demonstrate that PAK controls NF-kappaB activation by modulating the sensitivity of cells to ROS