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CREB5 — DUSP1
Text-mined interactions from Literome
Zhang et al., Cell Death Differ 2008
(Second Messenger Systems) :
Cyclic AMP inhibits JNK activation by
CREB mediated induction of c-FLIP ( L ) and
MKP-1 , thereby antagonizing UV-induced apoptosis
Cho et al., Inflamm Res 2009
:
In view of the potential roles of PKA and MSK for MKP-1 induction and the ability of H89 to inhibit these kinases, this study examined the effect of H89 on MKP-1 induction by LPS and the
role of cyclic-AMP response element binding protein (
CREB ) in the
MKP-1 induction ... Immunoblot, gel-shift, and chromatin-immunoprecipitation assays showed the activation of CREB by LPS, and the ability of H89 to inhibit it, suggesting that H89 's inhibition of
CREB may
affect MKP-1 induction ... Experiments using MAPK inhibitors showed that MAPKs are involved in
CREB phosphorylation and
MKP-1 induction , suggesting that CREB mediated MKP-1 induction serves in part as a feedback-inhibitory loop of MAPKs ... Our results demonstrate that H89 inhibits the activation of
CREB and the CREB mediated
MKP-1 induction by LPS, which may result from its inhibition of PKA and MSK
Casals-Casas et al., Eur J Immunol 2009
:
CREB and AP-1 activation
regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation