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CRK — IL2
Text-mined interactions from Literome
Cannons et al., J Immunol 2000
(MAP Kinase Signaling System) :
In contrast, following differentiation into Th1 or Th2 cells,
p38 inhibition
blocked IL-2 and IFN-gamma without affecting IL-4 secretion
Oda et al., Biochem Biophys Res Commun 2000
:
Thrombopoietin and
interleukin-2 induce association of
CRK with STAT5
Tham et al., J Immunol 2001
(MAP Kinase Signaling System) :
Together these results demonstrate that activation of at least ERK and
p38 is
essential for
IL-2 production by CD8 T cells and that up-regulation of these mitogen activated protein kinases, along with Janus kinase, is defective in AINR cells
Garcia-Cao et al., EMBO Rep 2003
(MAP Kinase Signaling System) :
Consistent with recent reports demonstrating the antagonistic actions of NF-kappaB and c-Jun amino-terminal kinase (JNK) signalling, we have found that Par4 ( -/- ) cells show a reduced activation of the sustained phase of JNK and
p38 stimulation by TNF-alpha and
interleukin 1
Zvalova et al., Glia 2004
:
Therefore,
interleukin-1beta (IL-1beta), which contributes to stroke induced brain injury and
activates p38/SAPK2 , and hyperosmolarity induced by sorbitol, a potent stimulus of p38/SAPK2 in non-neuronal cells, were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes
Wijagkanalan et al., Mol Pharmacol 2008
(Pneumonia) :
DPML significantly inhibited tumor necrosis factor alpha,
interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and
inhibited NFkappaB and
p38 mitogen activated protein kinase activation in the lung
Cuong et al., Life Sci 2009
(Inflammation...) :
Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha,
interleukin (IL)-6 , and IL-12 p40, and the
activation of ERK1/2 and
p38
Woehrle et al., J Leukoc Biol 2010
:
Blocking or silencing of Panx1 or of P2X1, P2X4, or P2X7 receptors blunts HS-induced
p38 MAPK activation and the stimulatory
effects of HS on TCR/CD28 induced
IL-2 gene transcription
Byun et al., Biochem Biophys Res Commun 2012
(Inflammation) :
In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a,
interleukin [ IL]-1ß, and IL-6 ) and
activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ),
p38 , c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR