◀ Back to BRCA1

BRCA1 — CHEK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CHEK1 → BRCA1 (increases, BRCA1 Activity)
  Evidence: BRCA1 is necessary for the activation of CHK1, which leads to DNA-damage-induced G2 arrest

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BRCA1 — CHEK1 (physical association, affinity chromatography technology) Yarden et al., Nat Genet 2002*
• IRef Biogrid Interaction: BRCA1 — CHEK1 (direct interaction, enzymatic study) Inoue et al., EMBO J 2007*
• IRef Intact Interaction: CHEK1 — BRCA1 (physical association, anti bait coimmunoprecipitation) Yarden et al., Nat Genet 2002*
• IRef Intact Interaction: CHEK1 — BRCA1 (colocalization, confocal microscopy) Yarden et al., Nat Genet 2002*