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MAPK12 — TIMP1

Text-mined interactions from Literome

Domeij et al., J Periodontal Res 2004 : Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production
Studer et al., J Orthop Res 2005 : In contrast, COX2 inhibition did not modulate TIMP-1 production while p38 MAPK inhibitors potentiated TGF-beta stimulated production of TIMP-1 in IL-1 activated cartilage ... p38 MAPK inhibition blunts TGF-beta stimulation of proteoglycan synthesis, but increases TIMP-1 synthesis
Morquette et al., Arthritis Rheum 2006 (Osteoarthritis) : In isolated OA chondrocytes, HNE inhibited the expression of CII and tissue inhibitor of metalloproteinases 1 and induced MMP-13 mainly through activation of p38 MAPK
Bigelow et al., Breast Cancer Res Treat 2009 (Breast Neoplasms) : However, overexpression of TIMP-1 in MDA-MB-231 cells resulted in inhibition of cell invasion and enhanced phosphorylation of p38 MAPK and AKT in vitro
Polimeni et al., PloS one 2013 (MAP Kinase Signaling System) : p38 MAPK and NF-?B inhibitors blocked all nHZ effects on TIMP-1 and pro-inflammatory molecules
Yamashita et al., FEBS Lett 1996 (Osteosarcoma) : We also found that either TIMP stimulated an increase in mitogen activated protein ( MAP ) kinase activity, suggesting that MAP kinase plays a role in TIMP dependent growth signaling