Rivera et al., Int Arch Allergy Immunol 2001
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Vav1 deficiency also affected secretion, although not to the extent of LAT deficiency, and inhibited IL-2 and IFN-gamma production
Kaminuma et al., FEBS Lett 2002
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Vav induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity ... The role of Vav in the transcriptional regulation of the human interferon-gamma (IFN-gamma) promoter was investigated ... Finally, coexpression of a dominant negative Rac1 mutant suppressed Vav mediated upregulation of the transcriptional and DNA binding activity of the proximal NFAT/AP-1 site and the AP-1/YY1 site, as well as the complete IFN-gamma promoter activity ... Vav activates the IFN-gamma promoter via upregulation of AP-1 binding through a Rac1/JNK pathway