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IFNG — SLAMF1

Text-mined interactions from Literome

Meroni et al., Clin Immunol 1999 (HIV Infections) : SLAM engagement augments T cell expansion and interferon-gamma (IFN-gamma) production independently of CD28 ... Results showed that : ( 1 ) SLAM expressing CD4 ( + ) and CD8 ( + ) lymphocytes diminish in group A patients compared to both group B patients and HC ; ( 2 ) SLAM expression on CD4 ( + ) lymphocytes is preferentially associated with the lack of CD7 on cell surface ( CD4 ( + ) CD7 ( - ) produce IL-10 but not IFN-gamma ) ; ( 3 ) SLAM engagement increases HIV env peptide stimulated, but neither tetanus toxoid- nor PHA stimulated proliferation of peripheral blood mononuclear cells ( PBMC ) in patients but not in HC ; and ( 4 ) SLAM engagement augments IFN-gamma and reduces IL-10 production by env peptide stimulated PBMC of HIV infected individuals
Henning et al., Eur J Immunol 2001 (Calcium Signaling...) : SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production
García et al., J Immunol 2001 (Leprosy) : Engagement of SLAM by an agonistic mAb up-regulated IFN-gamma production from tuberculoid patients and slightly increased the levels of IFN-gamma in lepromatous patients ... In addition, IFN-gamma augmented SLAM expression on M. leprae stimulated peripheral blood T cells from leprosy patients ... Our data suggest that the local release of IFN-gamma by M. leprae activated T cells in tuberculoid leprosy lesions leads to up-regulation of SLAM expression ... Failure of T cells from lepromatous leprosy patients to produce IFN-gamma in response to M. leprae contributes to reduced expression of SLAM
Quiroga et al., Medicina (B Aires) 2004 (Leprosy...) : [ The SLAM associated protein (SAP) regulates IFN-gamma expression in leprosy ] ... The SLAM associated protein (SAP) regulates IFN-gamma expression in leprosy
Morita et al., Scand J Rheumatol 2006 (Arthritis, Rheumatoid) : In vitro modulation of the cytokine network by MTX, IFN-gamma, and IL-4 is one of the major targets for MTX, and production of IFN-gamma and IL-4 by PBMCs may be suppressed by SLAM on activated CD4+ T-cell in patients with RA
Quiroga et al., J Infect Dis 2007 (Tuberculosis, Pulmonary) : Interestingly, CD31 bound to SLAM associated protein (SAP) , an IFN- gamma inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN- gamma response to M. tuberculosis
Isomäki et al., J Allergy Clin Immunol 1999 (Arthritis, Reactive...) : In addition, the engagement of SLAM on T cells preferentially induced IFN-gamma production even by allergen-specific TH2 clones