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IFNG — SERPING1
Text-mined interactions from Literome
Liu et al., Biochem Biophys Res Commun 2002
:
IFN-gamma induction of
C1 inhibitor (C1INH) is
mediated by an
IFN-gamma activated sequence ( GAS ), via binding of signal transducer and activator of transcription 1 ( STAT1 )
Schwögler et al., Hepatology 1992
:
C1-esterase inhibitor synthesis was
increased 6-fold to 10-fold by
interferon-gamma ... Because
C1-esterase inhibitor synthesis is
increased by advancing culture time and by the inflammatory mediator
interferon-gamma , we suggest that fat storing cells may enhance the deposition of extracellular matrix proteins by inhibiting their degradation
Lappin et al., Biochem J 1992
:
IFN-gamma did not affect the stability of C3, factor H or C4 bp mRNAs, but
increased the stability of factor B and
C1-inh mRNAs and decreased the stability of C2 mRNA
Zuraw et al., J Biol Chem 1990
(Acute-Phase Reaction) :
The stimulatory
effects of interleukin-6 and
interferon gamma on
C1INH synthesis are separate and are differentially modulated by interleukin-1
Heda et al., Blood 1990
:
These combined studies indicate that
IFN-gamma can
increase C1 INH protein expression in vitro and in vivo
Lotz et al., J Immunol 1987
:
In the
presence of
interferon (IFN)-gamma ,
C1INH was detectable within 24 hr and continued to be released at high levels throughout an 8-day culture period
Heda et al., Blood 1996
:
Actinomycin D and 5,6-dichloro-1-beta-ribofuranosylbenzimidazole abolished
IFN-gamma induced
C1 INH mRNA expression
Knittel et al., J Hepatol 1997
:
Among the protease inhibitors,
interferon-gamma induced
C1-esterase inhibitor synthesis, while tumour necrosis factor-alpha stimulated plasminogen activator inhibitor type 1 production
Zahedi et al., J Immunol 1997
(Carcinoma, Hepatocellular...) :
The
induction of
C1inh synthesis by
IFN-gamma is primarily regulated at the transcriptional level, and is controlled by elements in the 5 ' flanking region and the first intron of the C1inh gene ... The results indicate that STAT-1alpha binds to GAS 4, which is the primary element in the 5 ' flanking region responsible for
IFN-gamma induction of the
C1inh gene
Veerhuis et al., Acta Neuropathol 1998
(Alzheimer Disease) :
Since
IFN-gamma is apparently lacking in the brain parenchyma, and amyloid plaque associated cytokines ( IL-1beta, IL-6, TNF-alpha ) do not
stimulate C1-Inh expression in vitro, the nature of the stimulus responsible for neuronal C1-Inh expression in AD brains remains to be investigated
Prada et al., Immunobiology 1998
(Acute-Phase Reaction...) :
Interferon-gamma and alpha (IFN) , colony stimulating factor-1, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) all
induce C1-INH synthesis in a variety of cell types