Gene interactions and pathways from curated databases and text-mining

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CXCL11 — IFNG

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sauty et al., J Immunol 1999 : We found that IFN-gamma , but not TNF-alpha or IL-1 beta, strongly induced IP-10, Mig, and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types
Tensen et al., Biochim Biophys Acta 1999 : For these cell types, IFN-gamma was a potent inducer of CXCL 11 transcription, which was synergistically enhanced by TNF-alpha
Dwinell et al., Gastroenterology 2001 (Bacterial Infections...) : Interferon (IFN)-gamma stimulation increased mRNA expression and the polarized basolateral secretion of these chemokines by human colon epithelial cell lines ; infection with enteroinvasive bacteria, or stimulation with the proinflammatory cytokines tumor necrosis factor alpha and interleukin 1alpha, strongly potentiated IFN-gamma induced epithelial cell IP-10, Mig, and I-TAC production
Sheikh et al., Ann N Y Acad Sci 2001 : Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10, MIG, and I-TAC expression induced by IFN-gamma in human endothelial cells
Hamilton et al., Scand J Immunol 2002 (Encephalomyelitis, Autoimmune, Experimental) : IFN-gamma regulates murine interferon-inducible T cell alpha chemokine (I-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis ( EAE ) ... Analysis of the progenitor DC lines and Con A cultures demonstrated that murine I-TAC is primarily regulated by interferon (IFN)-gamma via interferon regulatory factor (IRF)-1
Hardaker et al., FASEB J 2004 (Inflammation...) : In primary cultured hASM cells taken from normal donors, CXCL10 protein expression was induced by IFN-gamma and TNF-alpha, cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Hillyer et al., Clin Exp Immunol 2003 : In combination with TNF-alpha, IFN-gamma suppressed CXCL8 but enhanced CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Proost et al., J Leukoc Biol 2004 (Arthritis, Infectious...) : Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids ... In vitro, IFN-gamma and TLR3 ligation by double stranded RNA ( dsRNA ) induced the expression of CXCL9 and CXCL11 in leukocytes and skin-muscle fibroblasts, whereas ligation of TLR2, TLR4, TLR5, and TLR9 by peptidoglycan ( PGN ), lipopolysaccharide (LPS), flagellin, and unmethylated CpG oligonucleotides, respectively, did not ... PGN and LPS, but not unmethylated CpG oligonucleotides, even inhibited IFN-gamma induced CXCL9 and CXCL11 expression in leukocytes ... In sharp contrast, in fibroblasts, the TLR ligands PGN, dsRNA, LPS, and flagellin synergized with IFN-gamma for the production of CXCL9 and CXCL11
Dajotoy et al., J Leukoc Biol 2004 (Crohn Disease) : We found that IFN-gamma induced rapid and sustained gene expression of MIG, IP-10, and I-TAC in eosinophils, as detected by quantitative reverse transcriptase-polymerase chain reaction
Thomas et al., J Immunol 2004 (Bronchial Hyperreactivity) : In lymphocytes restimulated with CXCL9 and allergen in vitro, CXCL9 down-regulated IL-4 expression and up-regulated IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Ogawa et al., Clin Immunol 2004 (Sjogren's Syndrome) : Moreover, immunohistochemical assays of minor salivary glands ( MSG ) showed that I-TAC was predominantly located in the ductal epithelium adjacent to lymphoid infiltrates in the SS salivary gland, indicating that ductal epithelial cells produce I-TAC proteins in response to stimulation with IFNgamma secreted by lymphocytes that infiltrate into SS salivary glands
Sheikh et al., Cardiovasc Res 2005 (Arteriosclerosis) : Lysophosphatidylcholine posttranscriptionally inhibits interferon-gamma induced IP-10, Mig and I-Tac expression in endothelial cells ... Northern blotting showed that lysoPC transiently and dose-dependently inhibited the IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48, interferon regulatory factor-1 and guanidine binding protein-1 ... LysoPC selectively inhibits IFN gamma induced IP-10, I-Tac and Mig expression in endothelial cells, at least in part, by reducing mRNA stability
McInnis et al., Invest Ophthalmol Vis Sci 2005 : In contrast, stimulation with TNF-alpha, IL-1alpha, or IFN-gamma induced levels of MIG and I-TAC that were not significantly greater than constitutive levels
Pechkovsky et al., Respir Res 2005 : IFN-gamma , alone or in combination with IL-1beta and TNF-alpha resulted in an increase in CXCL10, CXCL11 , and CXCL9 mRNA expression and generation of CXCL10 protein by AEC-II or A549 cells
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006 : Keratinocyte cultures established from normal skin of healthy donors were activated by IFN-gamma in the absence or presence of desloratadine and loratadine, and tested for the release of CCL5/RANTES, CXCL8/IL-8 , CCL17/TARC and CXCL10/IP-10 ... Desloratadine and loratadine inhibited the constitutive and IFN-gamma induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Bandyopadhyay et al., Biochem Pharmacol 2006 : In addition, apigenin inhibits IFNgamma stimulated secretion of monokines, CXCL-9 , and -10 in MC3T3-E1 cells
Hirota et al., J Immunol 2006 : In the present study, we explored expression and possible functions of CXCL11 , a CXC chemokine strongly induced by IFN-gamma , and its receptor CXCR3 in the human endometrium ... IFN-gamma stimulated the protein levels of CXCL11 in a dose dependent manner in EEC and ESC
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9), CXCL10 , and CXCL11 in human keratinocytes ... Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes ... Although prolactin alone was ineffective, it enhanced IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... Although prolactin alone was ineffective, it enhanced IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10, and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... These results suggest that prolactin may enhance IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes via activation of STAT1, NF-kappaB, and IRF-1 through JAK2 and MEK/ERK pathways
Kanda et al., Eur J Immunol 2007 : IL-18 enhances IFN-gamma induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes ... IL-18 enhances IFN-gamma induced production of CXCL9, CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... These results suggest that IL-18 may potentiate IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes by activating NF-kappaB, STAT1, or IRF-1 through PI3 K/Akt and MEK/ERK pathways
Taubert et al., Vet Res Commun 2008 : Furthermore, IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8 , CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Happel et al., Alcohol 2007 (Alcoholic Intoxication...) : IP-10, MIG, and I-TAC in response to LPS were enhanced by exogenous interferon (IFN)-gamma , and these responses were blunted by exposure to ethanol
Yuzawa et al., Life Sci 2008 : Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells ... The RNA interference against RIG-I resulted in the suppression of the IFN-gamma induced CXCL11 expression
Sumida et al., Arch Med Res 2008 (Lung Diseases, Interstitial) : However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-alpha and induction of Mig by IFN-gamma
Helbig et al., J Virol 2009 (Hepatitis C, Chronic) : Furthermore, HCV can selectively increase CXCL11 expression in response to IFN-gamma and TNF-alpha stimulation that may play a role in the pathogenesis of HCV related liver disease
Sanmiguel et al., Cell Signal 2009 (Psoriasis) : Inhibition of IRAK1 activity through RNAi or expression of a dominant negative mutant blocked production of CCL5 and CCL20 but had no effect upon the IL-1 enhancement of IFN-gamma induced CXCL9, CXCL10 and CXCL11 production
Antonelli et al., J Clin Endocrinol Metab 2009 (Graves Disease...) : It has been studied how IFNgamma and TNFalpha stimulation and PPARgamma activation affect CXCL9 and CXCL11 secretion in primary cultures of thyrocytes, orbital fibroblasts, and preadipocytes
Milks et al., Liver Int 2009 (Disease Models, Animal...) : Ifng is dichotomous in the regulation of distinct chemokine subfamilies : specifically, Ifng is critical for overexpression of specific CXCL genes but dispensable for overexpression of specific CCL genes
Benson et al., PloS one 2009 : Using chromatin immunoprecipitation, we found that TLR2 stimulation inhibited IFN-gamma induced RNA polymerase II binding to the CIITA and CXCL11 promoters
Cole et al., J Exp Med 1998 : Stimulation of astrocytes with IFN-gamma and IL-1 together results in an approximately 400,000-fold increase in I-TAC mRNA expression, whereas stimulating monocytes with either of the cytokines alone or in combination results in only a 100-fold increase in the level of I-TAC transcript