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TAT — TNF

Text-mined interactions from Literome

Mayne et al., J Immunol 2000 (Calcium Signaling) : HIV-1 protein Tat is neurotoxic and increases macrophage and microglia production of TNF-alpha , a cytopathic cytokine linked to the neuropathogenesis of HIV dementia ... Accordingly, we tested the hypothesis that Tat induced TNF-alpha production was dependent on the release of intracellular calcium from IP3 regulated calcium stores in primary macrophages ... Xestospongin C, BAPTA-AM, U73122, and bisindolylmalemide significantly inhibited Tat induced TNF-alpha production ... These results demonstrate that in macrophages, Tat induced release of calcium from IP3-sensitive intracellular stores and activation of nonconventional PKC isoforms play an important role in Tat induced TNF-alpha production
Chiao et al., AIDS Res Hum Retroviruses 2001 : HIV type 1 Tat inhibits tumor necrosis factor alpha induced repression of tumor necrosis factor receptor p55 and amplifies tumor necrosis factor alpha activity in stably tat transfected HeLa Cells
Flora et al., Exp Neurol 2003 : Moreover, synergistic effects of Tat plus METH on the tumor necrosis factor-alpha and interleukin-1beta mRNA levels were observed in the striatal region
Buonaguro et al., J Virol 1992 (Inflammation) : As TNF can increase the production of IL-1 and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune, vascular, and central nervous systems, the activation of TNF by Tat may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease
Contreras et al., J Soc Biol 2003 (MAP Kinase Signaling System) : [ HIV-1 Tat induces TNF-alpha production by human monocytes : involvement of calcium and PKC pathways ]
Fotheringham et al., Virology 2004 (Inflammation) : Because activation of adenosine receptors decreases production of the pro-inflammatory cytokine TNF-alpha in several experimental paradigms both in vitro and in vivo, we hypothesized that adenosine receptor activation would control both increased intracellular calcium and TNF-alpha production induced by Tat ... Tat induced TNF-alpha production was inhibited 90 +/- 6 % by CGS 21680 and concurrent treatment with okadaic acid blocked the inhibitory actions of CGS 21680
Contreras et al., Virology 2005 : Interestingly, we demonstrate that Tat induced calcium mobilization is tightly linked to TNF-alpha production, thus indicating that Tat induced mobilization and TNF-alpha production are entirely mediated by DHP receptors, as shown by their total inhibition by nimodipine, calcicludine, or anti-alpha1D antisense oligonucleotides
Theodore et al., Neurobiol Dis 2006 (AIDS Dementia Complex...) : Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction ... The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA ... The increase in TNF-alpha induced by Tat + MA was not significantly different from that induced by Tat alone
Hui et al., Yao Xue Xue Bao 2006 : The effects of SPMG on Tat induced TNFalpha ( 4 h ), IL-1beta and IL-6 ( 6 h ) secretion in THP-1 cells were measured by ELISA
Turchan-Cholewo et al., Antioxid Redox Signal 2009 : Furthermore, inhibition of NADPH oxidase attenuated Tat induced release of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF) , and monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
El-Hage et al., PloS one 2008 : Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent
Ju et al., Exp Mol Med 2009 (AIDS Dementia Complex...) : Taken together, our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via MAPK-NF-kappaB dependent mechanisms as well as Tat induced TNF-alpha production in astrocytes
Kiebala et al., PloS one 2010 : Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat induced tumor necrosis factor-alpha production ... Moreover, RelB overexpression in microglial cells inhibited Tat induced TNFalpha synthesis in a manner that involved transcriptional repression of the TNFalpha promoter, and increased phosphorylation of RelA at serine 276, a prerequisite for increased RelB/RelA protein interactions ... Moreover, because Tat activates both RelB and TNFalpha in microglia, and because Tat induces inflammatory TNFalpha synthesis via NF-kappaB, we posit that RelB serves as a cryoprotective, anti-inflammatory, counter-regulatory mechanism for pathogenic NF-kappaB activation
Lee et al., Exp Neurol 2011 : Additionally, the inhibition of Tat induced production of MCP-1 and TNF-a via the inactivation of the ERK1/2 pathway may represent the anti-inflammatory mechanism of resveratrol in the hippocampus
Kim et al., Immune network 2011 : We further demonstrated that JNK activation was required for TAT-CD137Lct induced production of TNF-a , while activation of Erk and p38 MAPK were involved in IL-6 and TNF-a production
Chen et al., J Biol Chem 1997 : We examined the possibility that HIV protein Tat , which is released extracellularly from infected cells, may induce the production of TNF-alpha ... In addition, Tat induced TNF-alpha release was also linked to phospholipase C activation
Sawaya et al., J Neuroimmunol 1998 : Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells ... TNFalpha mRNA level was increased by mutant Tat spanning residues 1 to 48 in U-87MG cells, but not in SK-N-MC and Jurkat cells ... Activation of the TGFbeta-1 and TNFalpha promoters by wild-type Tat was severely affected by the mutant peptides spanning residues 2 to 36 and 1 to 48 suggesting that both truncated Tat peptides may function as dominant negative mutants over TNFalpha and TGFbeta-1 gene transcription
Ito et al., AIDS Res Hum Retroviruses 1998 : Tat at the same concentrations did not affect IL-10, IL-6, or TNF-alpha production
Biswas et al., J Acquir Immune Defic Syndr Hum Retrovirol 1998 : It was proposed that the mechanism of antiviral action of S9a was on the host cell, by blocking TNF-alpha transcription via a Tat induced tar independent loop, which decreases downstream NF-kappaB activation of HIV-1 long terminal repeat ( LTR )
Mayne et al., Neuroimmunomodulation 1998 (AIDS Dementia Complex...) : We review our data showing the induction of TNF-alpha by Tat in primary human fetal astrocytes, human peripheral blood mononuclear cells, macrophages, and astrocytic and macrophage cell lines ... Nonetheless, these studies suggest that Tat is an important inducer of TNF-alpha production and thus may play a key role in the pathogenesis of HIV related neurological disease
Matsutani et al., J Surg Res 1998 (Carcinoma...) : Methylprednisolone treatment effectively inhibited the increases in TNF-alpha and IL-6 and the decreases in AT-III and albumin, but did not inhibit the increases in PMN-elastase and TAT levels