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CCND1 — SRC
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nebigil et al., Proc Natl Acad Sci U S A 2000
(MAP Kinase Signaling System) :
Inhibition of
c-Src activity by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ) or depletion of c-Src is
sufficient to abolish the 5-HT induced ( i ) PDGFR tyrosine kinase phosphorylation and MAPK activation, ( ii )
cyclin D1 and cyclin E expression levels, and ( iii ) thymidine incorporation
Simon et al., Am J Physiol Lung Cell Mol Physiol 2002
:
Inhibition of the
Src and JAK kinases
blocked PDGF stimulated gene expression of the STAT target genes
cyclin D1 and c-myc
Acosta et al., Mol Endocrinol 2003
:
Moreover, we show that both
c-Src/PI3K and c-Src/Fak/Erk1/2 pathways are
involved in the up-regulation of c-myc and
cyclin d1 expression mediated by PRL
Mamidipudi et al., Mol Cell Biol 2004
(Neoplasms) :
Conversely, downregulation of RACK1 by short interference RNA activates
Src mediated signaling,
induces Myc and
cyclin D1 , and accelerates G ( 1 ) /S progression
Jin et al., Cancer Res 2007
(Cell Transformation, Neoplastic) :
Suppression of
c-Src by RNA interference in NIH3T3-ETV6-NTRK3 cells
resulted in markedly decreased expression of
cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt
Jin et al., J Biol Chem 2008
(Cell Transformation, Neoplastic) :
Suppression of
c-Src by RNA interference in highly metastatic 4T1 mammary cancer cells, which express endogenous TrkC,
resulted in markedly decreased expression of
cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt
Boonyaratanakornkit et al., Steroids 2008
:
Progestin induction of
CCND1 was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically
reduced in the presence of inhibitors of
Src or MAPK
Aziz et al., Mol Cell Biol 1999
:
Activation of Raf,
v-Src , and MEK1
led to induced expression of c-Myc and
cyclin D1