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CASP10 — CCND1
Text-mined interactions from Literome
Yu et al., Oncogene 2004
(Leukemia) :
Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites, as well as the
caspase dependent downregulation of
cyclin D1
Kameswaran et al., Biomed Pharmacother 2009
(Laryngeal Neoplasms) :
Indirubin-3-oxime induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of
cyclin D1 and
activation of
caspase-3
Kong et al., Cancer Lett 2010
(Neovascularization, Pathologic...) :
The mechanisms involved inhibition of NF-kappaB activity and consequent inhibition of Bcl-2,
cyclin D1 and VEGF, and
activation of
caspase-3
Park et al., Phytother Res 2010
:
Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ), the downregulation of
cyclin D1 , anti-apoptotic protein, Bcl-2, the release of cytochrome c, and the
activation of caspase-9, caspase-3 and
caspase-8