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PARP12 — TP53

Text-mined interactions from Literome

Mandir et al., J Neurochem 2002 (Disease Models, Animal...) : p53 is a target of the nuclear enzyme Poly ( ADP-ribose ) polymerase ( PARP ), and PARP is activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) -induced neurotoxicity
Watanabe et al., Biochem Biophys Res Commun 2004 : Furthermore, in vitro, PARP-1 inhibited phosphorylation of p53 on serine 15 and ( 32 ) P-incorporation into p53 by ATM in a DNA dependent manner
Zhang et al., Clin Cancer Res 2006 (Melanoma...) : This was characterized by lack of DNA fragmentation, delayed externalization of phosphatidylserine, caspase and p53 independence, and severe mitochondrial disruption, and was preceded by poly ( ADP ) ribose polymerase ( PARP ) activation and depletion of intracellular ATP, indicative of necrotic cell death
Canner et al., Br J Cancer 2009 (Rhabdomyosarcoma, Alveolar...) : However, RD2 and RH30 RMS cells, as well as human normal skeletal muscle cells, showed a minimal increase in p53 signalling and no induction of cleaved PARP and caspase-3
Lee et al., Oncol Rep 2010 (Adenocarcinoma...) : In this study, we examined the chemoresistance to 5-Fluorouracil ( 5-FU ) using MCF-7 breast cancer MTS. 5-FU ( 400 microM ) induced apoptosis in MCF-7 cell monolayer as determined by HO/PI staining, PARP cleavage, p53 induction , Bax induction, and Bcl-2 down-regulation
Ferraz da Costa et al., PloS one 2012 (Breast Neoplasms...) : The resveratrol induced cytotoxicity in these cells was partially mediated by p53 and involved the activation of caspases 9 and 7 and the cleavage of PARP
Wesierska-Gadek et al., Cancer Res 1999 : Here, we have investigated whether PARP deficiency may affect the expression and regulation of wild-type ( wt ) p53
Simbulan-Rosenthal et al., Biochem Biophys Res Commun 1998 (Burkitt Lymphoma) : The role of poly ( ADP-ribose ) polymerase ( PARP ), an abundant nuclear enzyme activated by DNA strand breaks, in the p53 response to y-irradiation was investigated in Burkitt 's lymphoma AG876 cells stably transfected with an inducible PARP antisense construct