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CARD8 — CASP7

Text-mined interactions from Literome

Zhou et al., Proc Natl Acad Sci U S A 1999 : Direct recruitment and activation of caspase-9 by Apaf-1 through the homophilic CARD/CARD ( Caspase Recruitment Domain ) interaction is critical for the activation of caspases downstream of mitochondrial damage in apoptosis
Pathan et al., J Biol Chem 2001 (Neoplasms) : TUCAN interferes with binding of Apaf1 to procaspase-9 and suppresses caspase activation induced by the Apaf1 activator, cytochrome c. Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1/caspase-9 dependent stimuli, including Bax, VP16, and staurosporine, but not by Apaf1/caspase-9 independent stimuli, Fas and granzyme B
Shiozaki et al., Proc Natl Acad Sci U S A 2002 : Oligomerization and activation of caspase-9 , induced by Apaf-1 CARD
Chamaillard et al., Cell Microbiol 2003 (Bacterial Infections...) : NBS-LRR proteins are characterized by three structural domains : a C-terminal leucine-rich repeat ( LRR ) domain able to sense a microbial motif, an intermediary nucleotide binding site (NBS) essential for the oligomerization of the molecule that is necessary for the signal transduction induced by different N-terminal effector motifs, such as a pyrin domain ( PYD ), a caspase activating and recruitment domain ( CARD ) or a baculovirus inhibitor of apoptosis protein repeat ( BIR ) domain
Checinska et al., BMC cancer 2006 (Carcinoma, Non-Small-Cell Lung) : Proteins interaction assays, and RNA interference in combination with cell viability and apoptosis assays were used to investigate the involvement of TUCAN in inhibition of caspase-9 and chemosensitivity NSCLC ... Furthermore, RNA interference mediated down-regulation of TUCAN did not restore cisplatin induced caspase-9 activation or affect cisplatin sensitivity in NSCLC cells
Ko et al., Am J Hum Genet 2009 (Bacterial Infections) : A loss-of-function allele of CARD8 , a reported inhibitor of the proinflammatory protease caspase-1 , was associated with increased cell death in vitro ( p = 0.013 )