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CD4 — TSLP

Text-mined interactions from Literome

Watanabe et al., Nat Immunol 2004 : These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4 ( + ) T cell homeostasis
Al-Shami et al., J Exp Med 2004 : A role for thymic stromal lymphopoietin in CD4 ( + ) T cell development
Rochman et al., J Immunol 2007 : TSLP can act directly on mouse CD4 ( + ) T cells, but in humans, the available data have indicated that TSLP receptors are not expressed on CD4 ( + ) T cells and that TSLP instead activates dendritic cells, which in turn promote the proliferation and differentiation of CD4 ( + ) T cells ... Our results establish that human CD4 ( + ) T cells are direct targets for TSLP
Edwards et al., Drug News Perspect 2008 (Asthma...) : These TSLP-DC stimulate CD4 ( + ) T cells to induce a proallergic cytokine profile, suggesting TSLP plays a crucial role in the initiation of the allergic cascade
Lu et al., J Exp Med 2009 : Whether thymic stromal lymphopoietin (TSLP) directly induces potent human CD4 ( + ) T cell proliferation and Th2 differentiation is unknown ... TSLP could only induce naive CD4 ( + ) T cells to differentiate into Th2 cells in the presence of allogeneic mDCs
Yu et al., Journal of the American Heart Association 2013 (Atherosclerosis) : Our results indicated that TSLP-DCs obtained the characteristics of tolerogenic dendritic cells and increased a generation of CD4 ( + ) latency associated peptide (LAP) ( + ) Tregs and nTregs when cocultured with naive T cells