◀ Back to CD4
CD3D — CD4
Pathways - manually collected, often from reviews:
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BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
MHC class II complex (HLA-DRA-HLA-DRB1)
→
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
(modification, collaborate)
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BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
CD4
(modification, collaborate)
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BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
LCK
(modification, collaborate)
-
BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D)
(modification, collaborate)
-
BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD4
→
TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK)
→
ZAP70
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK)
→
TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
ZAP70
→
TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
-
BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
(modification, collaborate)
-
BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
ZAP70
(modification, collaborate)
-
BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
→
ZAP70
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK)
→
LCK
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK)
→
TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
LCK
→
TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
MHC class II complex (HLA-DRA-HLA-DRB1)
→
TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4)
→
CD4
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4)
→
TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D)
(modification, collaborate)
-
BioCarta t cell receptor signaling pathway:
CD4
→
TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D)
(modification, collaborate)
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
PKC theta (PRKCQ)
(modification, activates)
Liu et al., J Biol Chem 2000, Bi et al., Nat Immunol 2001, Díaz-Flores et al., J Biol Chem 2003, Imboden et al., J Exp Med 1985
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
(modification, activates)
Liu et al., J Biol Chem 2000, Bi et al., Nat Immunol 2001, Díaz-Flores et al., J Biol Chem 2003, Imboden et al., J Exp Med 1985
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(modification, collaborate)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
ZAP-70 (ZAP70)
(modification, collaborate)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, activates)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
ZAP-70 (ZAP70)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1)
(modification, activates)
Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Exley et al., J Biol Chem 1994, Prasad et al., Mol Cell Biol 1993, Zhang et al., Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL)
(modification, collaborate)
Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
CBL (CBL)
(modification, collaborate)
Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL)
→
CBL (CBL)
(modification, collaborate)
Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(modification, activates)
Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
ITK (ITK)
(modification, activates)
Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
SHP2 (PTPN11)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, inhibits)
Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, activates)
Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database CXCR4-mediated signaling events:
G beta/gamma complex (GNB1-GNG2)
→
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
(modification, activates)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
G beta/gamma complex (GNB1-GNG2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, activates)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1)
→
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
(modification, inhibits)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, inhibits)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
LCK (LCK)
→
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
(modification, collaborate)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
LCK (LCK)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CXCR4-mediated signaling events:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2)
→
CBL (CBL)
(modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2)
→
SLAP-2 (SLA2)
(modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
CBL (CBL)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
SLAP-2 (SLA2)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
LAT/GRAP2/SLP76 complex (LAT-GRAP2-LCP2)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Liu et al., J Immunol 2000
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
HPK1 (MAP4K1)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Liu et al., J Immunol 2000
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D)
→
CD4 (CD4)
(modification, collaborate)
Irvine et al., Nature 2002, Call et al., Cell 2002
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Irvine et al., Nature 2002, Call et al., Cell 2002
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
CD4 (CD4)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Irvine et al., Nature 2002, Call et al., Cell 2002
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
peptide/MHC II complex (HLA-DRA-HLA-DRB1)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Irvine et al., Nature 2002, Call et al., Cell 2002
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2)
→
3BP2 (SH3BP2)
(modification, collaborate)
Deckert et al., Immunity 1998
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Deckert et al., Immunity 1998
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
3BP2 (SH3BP2)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Deckert et al., Immunity 1998
Evidence: physical interaction
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
Calcineurin A alpha-beta B1 ()
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, inhibits)
Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
CSK/PAG1 complex (CSK-PAG1)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, collaborate)
Brdicka et al., J Exp Med 2000
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
SHP1 (PTPN6)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2)
(modification, activates)
Yu et al., FEBS J 2006
Evidence: mutant phenotype
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
LCK (LCK)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, activates)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
LCK (LCK)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
Calcineurin A alpha-beta B1 ()
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, inhibits)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2)
→
None
(modification, activates)
Deckert et al., Immunity 1998
Evidence: reporter gene
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
ITK (ITK)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, activates)
Paz et al., Biochem J 2001, Perez-Villar et al., Biochemistry 2002, Zhang et al., Cell 1998
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
SHP2 (PTPN11)
→
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
(modification, inhibits)
Kwon et al., EMBO J 2005, da Silva et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(modification, activates)
Raab et al., Proc Natl Acad Sci U S A 1995
Evidence: mutant phenotype, assay
-
Reactome Reaction:
CD3D
→
CD4
(indirect_complex)
Leo et al., J Clin Invest 2002, Huang et al., J Biol Chem 2004, Boggon et al., Oncogene 2004, Palacios et al., Oncogene 2004, Wilkinson et al., Expert reviews in molecular medicine 2005
-
Reactome Reaction:
CD3D
→
CD4
(reaction)
Huang et al., J Biol Chem 2004, Palacios et al., Oncogene 2004, Wilkinson et al., Expert reviews in molecular medicine 2005, van Oers et al., Semin Immunol 1995, Chu et al., Immunol Rev 1998
Text-mined interactions from Literome
Portolés et al., Cell Immunol 1999
:
Antibody induced
CD3-CD4 coligation
inhibits TCR/CD3 activation in the absence of costimulatory signals in normal mouse CD4 ( + ) T lymphocytes
Ulivieri et al., Eur J Immunol 1999
(Calcium Signaling) :
While no calcium mobilization was measurable in cells defective for
TCR/CD3 expression in
response to
CD4 engagement, the Ras/MAP kinase pathway could be partially activated
Sanzenbacher et al., J Immunol 1999
:
SLP-76 binding to p56lck : a role for SLP-76 in
CD4 induced desensitization of the
TCR/CD3 signaling complex
Turka et al., J Immunol 1991
:
Taken together, our data suggest a model of thymic development in which
CD4 or CD8 may
enhance TCR/CD3 signaling upon coligation by an MHC molecule
Zhong et al., PloS one 2009
:
The ligation of
TCR/CD3 on CD4 or CD8 T cells
led to CD3 nanoscale co-clustering or interaction with
CD4 or CD8 co-receptors forming 200-500 nm nano-domains or > 500 nm micro-domains
Zuñiga-Pflücker et al., J Exp Med 1989
:
The
TCR/CD3 upregulation occurs in the double positive population, and may
result from
CD4 signaling after mAb engagement, or may be a consequence of the blocked CD4-class II interactions
Thome et al., J Exp Med 1995
:
Evidence has suggested that the association of CD4 with
TCR/CD3/zeta requires the interaction of the protein tyrosine kinase p56lck with
CD4