Wagner et al., Arterioscler Thromb Vasc Biol 2002
:
One consequence of this statin dependent downregulation of CD40 expression was a decrease in CD40 ligand induced endothelial interleukin-12 expression
Schönbeck et al., Circulation 2002
(Coronary Stenosis) :
Platelet enriched plasma of mice deficient in CD40L showed markedly delayed fibrin clot formation, suggesting a role for the ligand in blood coagulation and supporting the hypothesis that statin mediated reduction in CD40/CD40L expression might limit thrombosis