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TGFB1 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kang et al., Perit Dial Int 1999
(Peritonitis) :
Stimulation with IL-1beta ( 1 ng/mL ) or
TNFalpha ( 1 ng/mL )
resulted in a significant increase in
TGFbeta1 mRNA expression after 48 hours : 2.7 and 2.1 times the control level, respectively ... However,
TNFalpha induced increase in
TGFbeta1 mRNA expression was not translated intoTGFbeta1 protein secretion, while IL-1beta stimulation induced a significant increase in TGFbeta1 protein secretion as well as TGFbeta1 mRNA expression
Schiött et al., Immunol Lett 2000
:
TGF-beta1 induced IL-10 production, slightly decreased
TNF-alpha production and decreased IFN-gamma production
Verrecchia et al., J Biol Chem 2000
:
Tumor necrosis factor-alpha inhibits
transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation
Vermes et al., J Bone Joint Surg Am 2001
(Osteolysis) :
Exogenous
tumor necrosis factor-alpha also
enhanced the release of interleukin-6 ( p < 0.01 ) and
transforming growth factor-beta1 ( p < 0.05 ), whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well
Warshamana et al., Exp Mol Pathol 2001
:
TNF-alpha , PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells : tnf-alpha
induces TGF-beta(1)
Baroni et al., Arch Dermatol Res 2001
:
Moreover, we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by
inhibiting IL-6 and
TNF-alpha and by upregulating IL-10 and
TGF-beta1
Pilette et al., J Immunol 2002
:
The suppressive effect of IL-9 on the respiratory burst and
TNF-alpha production in LPS stimulated monocytes was significantly
inhibited by
anti-TGF-beta1 , but not by anti-IL-10Rbeta mAb
Basu et al., Glia 2002
(Brain Injuries...) :
TGFbeta1 blocked the induction of the tyrosine kinases, Cox-2, and the induction of IL-6 and
TNFalpha mRNAs
Xiao et al., Brain Behav Immun 2002
:
In sharp contrast,
TGF-beta 1 , in the presence of GM-CSF, dramatically
up-regulated the expression of
TNF-alpha and TGF-beta 1 mRNA
Phillips et al., Gut 2003
:
MMP2 secretion by PSCs was significantly increased by
TGF-beta1 and IL-6, but was not
affected by
TNF-alpha
Vasu et al., Int Immunol 2003
(Thyroiditis, Autoimmune) :
Our data suggest that engagement of CTLA-4 expressed on activated autoreactive T cells in close proximity to the thyroid can
increase the number of regulatory T cells and their ability to produce
TGF-beta1 , with a concomitant reduction in IFN-gamma and
TNF-alpha , resulting in suppression of EAT
Tao et al., Hua Xi Yi Ke Da Xue Xue Bao 2001
(Diabetes Mellitus, Experimental) :
TNF-alpha could
enhance the effect of high glucose on the secretion of
TGF-beta 1 , whereas insulin could inhibit it
Huang et al., Zhonghua Jie He He Hu Xi Za Zhi 2003
:
The secretion of
TNF-alpha by HMPC increased after incubation with 100 mg/L erythromycin for 3 or 5 days, and the secretion of
TGF-beta(1) increased markedly after incubation with lower or higher concentrations of erythromycin
Bry et al., Am J Obstet Gynecol 1992
(Obstetric Labor, Premature) :
Human amnion cells in monolayer culture were treated with interleukin-1,
tumor necrosis factor , or vehicle in the
presence or absence of
transforming growth factor-beta
Langhorne et al., Immunol Rev 2004
(Inflammation...) :
IFN-gamma and
TNF-alpha play a role in both protective immunity and the pathology of the infection, and the inflammatory disease may be
regulated by IL-10 and
transforming growth factor-beta
Gunnlaugsdottir et al., Int Immunol 2005
(Necrosis) :
Interestingly,
TGF-beta1 induced IL-10 and
TNFalpha secretion
Zhang et al., J Am Soc Nephrol 2005
:
TNF-alpha stimulation alone did not
increase TGF-beta1 synthesis
Sullivan et al., Am J Respir Cell Mol Biol 2005
(MAP Kinase Signaling System) :
Tumor necrosis factor-alpha induces
transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal regulated kinase pathway ... We recently reported that
TNF-alpha upregulates
TGF-beta(1) expression in primary mouse lung fibroblasts ( MLFs ), a key cell population in fibrogenesis
He et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005
:
TNF-alpha increases cell death by approximately 2-fold, which is attenuated by both EMD and
TGF-beta1
Shvedova et al., Am J Physiol Lung Cell Mol Physiol 2005
(Granuloma, Foreign-Body...) :
In vitro exposure of murine RAW 264.7 macrophages to SWCNT
triggered TGF-beta1 production similarly to zymosan but generated less
TNF-alpha and IL-1beta
Gao et al., Frontiers in bioscience : a journal and virtual library 2005
(Second Messenger Systems) :
IFN-gamma and
TNF-alpha inhibit expression of
TGF-beta-1 , its receptors TBETAR-I and TBETAR-II in the corpus luteum of PMSG/hCG treated rhesus monkey
François et al., Ann Rheum Dis 2006
(Disease Progression...) :
The immunohistological findings of a limited sample suggest a
role for BM in sacroiliitis, for
TNFalpha and IL6 in early, active lesions, and for
TGFbeta1 at the time of secondary cartilage and bone proliferation
Fain et al., Metabolism 2005
(Obesity, Morbid) :
The question of whether
tumor necrosis factor alpha (TNF-alpha) and/or interleukin 1 beta (IL-1 beta)
regulate the release of
TGF-beta1 was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody ... The release of
TGF-beta1 over 48 hours by adipose tissue explants was significantly enhanced in the
presence of both the inhibitor of
TNF-alpha and of IL-1 beta
Kaneki et al., J Biol Chem 2006
:
TNF inhibited the expression of bone morphogenetic protein and
transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
Li et al., J Biol Chem 2006
:
Surprisingly, this brief exposure to FC-AMs triggered a modest proinflammatory response in the phagocytes
: tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta were
induced , whereas the levels of
transforming growth factor-beta and IL-10 were not increased
Nagineni et al., J Cell Physiol 2007
:
RT-PCR analyses showed that
TNF-alpha and IL-1beta
increased the mRNA levels of both
TGF-beta1 and TGF-beta2
Babel et al., J Nephrol 2006
(Diabetic Nephropathies...) :
Since
TNF-alfa and IL-10 are involved in regulation of inflammation, and
TGF-beta 1 can
induce fibrosis and renal insufficiency - dominant features of end-stage renal disease ( ESRD ), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure
Suzuki et al., J Cell Physiol 1991
(Blast Crisis...) :
Third, leukemic cells of the two patients studied were revealed to secrete IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) constitutively ; the production by leukemic cells of IL-1 beta and
TNF-alpha was significantly
promoted by
TGF-beta 1
Satoh et al., J Cell Physiol 1992
:
Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is
suppressed by
transforming growth factor beta and interleukin 6
Srivastava et al., J Biol Chem 2007
:
TNF-alpha increased the activity of
transforming growth factor-beta activating kinase-1 ( TAK1 )
Yamasaki et al., Am J Respir Cell Mol Biol 2008
(Fibrosis...) :
Finally, our studies further demonstrated that TGF-beta(1) induces p21 via a TNF-alpha signaling pathway and that p21 is a negative modulator of
TGF-beta(1) induced
TNF-alpha expression
Gómez et al., FEMS Immunol Med Microbiol 2008
:
Cytokines are an integral component of the adaptive and innate immune response, particularly IL-1 beta, interferon,
tumor necrosis factor-alpha ,
transforming growth factor-beta and several chemokines
regulate innate immunity
Nishimura et al., Int J Immunopathol Pharmacol 2007
(Fibrosis...) :
Alveolar macrophages ( AMs ) exposed to asbestos are well known to produce
TNF-alpha , which
induces the production of
TGF-beta1 , leading to lung fibrogenesis
Turner et al., Eur J Immunol 1991
:
Transforming growth factor-beta 1 ( TGF-beta 1 ) mediates many immunosuppressive effects on immune cells and can
inhibit the production of
tumor necrosis factor and interleukin 1 (IL 1)
Lemaire et al., Mediators Inflamm 1996
:
Role of
transforming growth factor-beta(1) in down regulating
TNF production by alveolar macrophages during asbestos induced pulmonary fibrosis
Li et al., J Lipid Res 2008
:
Furthermore,
TNFalpha and cJun
attenuated TGFbeta1 stimulation of rat Cyp7a1
Sullivan et al., J Immunotoxicol 2008
(MAP Kinase Signaling System...) :
The latent form of
TGFbeta(1) is
induced by
TNFalpha through an ERK specific pathway and is activated by asbestos derived reactive oxygen species in vitro and in vivo ... The mechanism of
TNFalpha induction of
TGFbeta(1) expression appears to be complex, involving both transcriptional and post-transcriptional mechanisms
Cohen et al., Cancer Res 2009
(Carcinoma, Squamous Cell...) :
However, in HNSCC cells that retained residual TGFbeta signaling,
TGFbeta1 inhibited both constitutive and
tumor necrosis factor alpha stimulated NF-kappaB activity
Ghio et al., Eur J Immunol 2009
:
TGF-beta1 strongly reduced NK cell
mediated tumor cell lysis and production of pro-inflammatory cytokines such as
TNF-alpha and IFN-gamma
Bekeredjian-Ding et al., Immunology 2009
(Head and Neck Neoplasms) :
Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and
transforming growth factor-beta ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically
inhibit interferon-alpha ( IFN-alpha ) and
tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC
Sullivan et al., J Cell Mol Med 2009
:
TNF-alpha induces
TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation ... In the current study, we further investigated the molecular mechanisms involved in
TNF-alpha regulation of
TGF-beta(1) expression
Guan et al., Transplantation 2010
(Reperfusion Injury) :
Here, we showed that in cultures of HK-2 cells,
TGF-beta1 expression was
up-regulated by
tumor necrosis factor (TNF)-alpha ... Expression of
TGF-beta1 in TECs, potentially
induced by proinflammatory
TNF-alpha , renders TECs resistance to cell death
Khera et al., FEBS J 2010
:
The anti-inflammatory cytokine
transforming growth factor-beta1 ( TGF-beta1 ), which is involved in the homeostatic regulation of TNF-alpha,
causes post-transcriptional suppression of lipopolysaccharide (LPS) induced
TNF-alpha production ... Using RAW 264.7 cells and bone marrow derived macrophages ( BMDMphi ) stimulated with LPS and TGF-beta1, we show that
TGF-beta1 inhibits
TNF-alpha protein secretion, whereas TNF-alpha mRNA expression remains unchanged
Turner et al., Cytokine 1990
:
Furthermore, when a panel of stimuli were compared for their ability to induce IL 1,
TNF and IL 6 in the
presence or absence of
TGF beta 1 , IL 6 levels were augmented in the presence of TGF beta 1, while the induction of IL 1 and TNF was inhibited significantly
Brennan et al., Clin Exp Immunol 1990
(Arthritis, Rheumatoid) :
This was confirmed by the observation that neither
TGF-beta 1 or TGF-beta 2
inhibited spontaneous IL-1 or
TNF-alpha production by rheumatoid synovial mononuclear cells in culture
Kim et al., Cell Immunol 1990
:
The studies suggest that IL-1, IL-4, or
TNF-alpha mediate a proliferative signal on murine thymocytes independent of IL-6 and that the proliferative signals provided by these cytokines as well as IL-6 are inhibitable by rHu
TGF-beta 1
Cockerill et al., Lab Invest 1994
(Trisomy) :
CD34 expression of this cell line and the ability of
transforming growth factor-beta to
inhibit the
TNF-alpha induction of E-selectin was examined ... C11STH cells do not express CD34 or show
transforming growth factor-beta inhibition of
TNF-alpha induced E-selectin expression, functions indicative of primary, or early passage HUVECs
Chang et al., J Biol Chem 1995
:
Time course experiments revealed that
TGF-beta 1 initially
induced both cellular protein-tyrosine phosphorylation and simultaneous secretion of a novel extracellular matrix
TNF-resistance triggering (TRT) protein ( s ), which closely preceded the acquisition of TNF-resistance
Benveniste et al., Int J Dev Neurosci 1995
:
In this study, we demonstrate that
transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6)
inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Chao et al., Clin Immunol Immunopathol 1995
:
Tumor necrosis factor-alpha mediates the release of bioactive
transforming growth factor-beta in murine microglial cell cultures
Bellone et al., J Immunol 1995
:
Exogenous bioactive
TGF-beta 1 inhibited NK cell DNA synthesis and production of IFN-gamma,
TNF-alpha , and granulocyte-macrophage CSF (GM-CSF) by NK cultures consisting of > 98 % CD56+ cells
Reinhold et al., Cytokine 1994
:
In this study we have analysed in parallel the
effects of
TGF-beta 1 on both DNA synthesis and production of the cytokines IL-1, IL-2, IL-6, and
TNF-alpha by pokeweed mitogen stimulated peripheral blood mononuclear cells
Campbell et al., Biochim Biophys Acta 1994
(Joint Diseases) :
Tumor necrosis factor alpha (TNF alpha) reduced, and
transforming growth factor-beta ( TGF-beta ) and basic fibroblast growth factor (bFGF)
increased , the levels of PAI-1 antigen and mRNA in the culture fluids and cell extracts, respectively
Barnum et al., J Immunol 1994
(Inflammation) :
In this report, we show that
transforming growth factor-beta ( TGF-beta ) can significantly
inhibit the capacity of IFN-gamma, IL-1 beta, and
TNF-alpha to augment expression of the central component of complement C3 in the human astroglioma cell line D54-MG. Treatment of D54-MG cells with TGF-beta alone had no dose- or time dependent effect on basal C3 protein or mRNA levels
Offner et al., Am J Pathol 1996
:
Neither
tumor necrosis factor (TNF)-alpha nor interferon (IFN)-gamma ( both 10 ng/ml )
affected TGF-beta 1 or TGF-beta 2 synthesis by HPMCs. TGF-beta 3 could not be detected in any of the supernatant media
Buck et al., Am J Pathol 1996
(Cachexia...) :
The expression of
transforming growth factor-beta1 , a potent fibrogenic factor, was
inhibited by
TNF-alpha in the skin
Nishida et al., Am J Kidney Dis 1997
:
Exposure to VLDL, IDL, LDL, or a high concentration of HDL
enhanced the secretion of interleukin-6, platelet derived growth factor, and
transforming growth factor-beta by mesangial cells, whereas
tumor necrosis factor-alpha secretion was stimulated by oxidized LDL
Wang et al., Clin Orthop Relat Res 1997
(Bone Neoplasms...) :
Titanium, cobalt, and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly
enhanced the release of interleukin-1 beta and
tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells, whereas they did not alter the release of
transforming growth factor-beta 1
Fortunato et al., Am J Obstet Gynecol 1997
(Obstetric Labor, Premature) :
Interleukin-10 and
transforming growth factor-beta inhibit amniochorion
tumor necrosis factor-alpha production by contrasting mechanisms of action : therapeutic implications in prematurity ... This study was designed to detect the regulatory
effect of the immunoinhibitory cytokines interleukin-10 and
transforming growth factor-beta on the amniochorion production of
tumor necrosis factor-alpha ... This study suggests that interleukin-10 and
transforming growth factor-beta can
regulate tumor necrosis factor-alpha release from amniochorion under different conditions and by a different mechanism
Méndez-Samperio et al., Clin Diagn Lab Immunol 1998
(Tuberculosis, Pulmonary) :
The
effect of exogenous
transforming growth factor beta ( TGF-beta ) on Mycobacterium bovis BCG induced
tumor necrosis factor alpha (TNF-alpha) production by human mononuclear cells was studied
Danforth et al., Clin Cancer Res 1996
(Breast Neoplasms) :
We studied the
effect of
tumor necrosis factor alpha (TNF-alpha) on
transforming growth factor beta ( TGF-beta ) secretion by human breast cell lines to further characterize the antitumor effects of TNF-alpha