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APOB — TNF

Text-mined interactions from Literome

Walsh et al., J Lipid Res 1999 (Arteriosclerosis) : 17beta-estradiol reduces tumor necrosis factor-alpha mediated LDL accumulation in the artery wall ... We asked : 1 ) does TNF increase LDL accumulation in the artery wall and 2 ) can the TNF mediated increase in LDL accumulation be prevented by the antioxidant activity of estradiol ? ... Estradiol ( 65 pg/ml ) and alpha-tocopherol ( 6 mg/L ) both attenuated TNF mediated LDL accumulation ( P < 0.05 ), indicating that TNF may exert its effects on LDL accumulation through cellular production of oxygen derived free radicals
Nishida et al., Kidney Int Suppl 1999 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of IL-6, PDGF-AB, and TGF-beta by mesangial cells, whereas TNF-alpha secretion was stimulated by oxidized LDL
Sakurai et al., Kidney Int Suppl 1999 (Glomerulonephritis, Membranous...) : The effects of steroids and LDL-A on the production of IL-8, TNF-alpha , and MCP-1 by peripheral blood mononuclear cells ( PBMCs ) were also determined in some patients
Walsh et al., J Lipid Res 2000 : There was no effect of hormone replacement on rate of TNF induced LDL accumulation ( P = 0.451 ), while incubation of LDL with 65 pg/ml estradiol attenuated the TNF effect ( P < 0.01 )
Niemann-Jönsson et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : The present findings support the notion that LDL may activate arterial expression of TNF-alpha and suggest 1 possible mechanism for the inflammatory response in the early stages of atherosclerosis
Feng et al., Atherosclerosis 2001 : Oxidized LDL , as well as a combination of cholesterol and 25-hydroxycholesterol, induced tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR, by a maximum of two- to fourfold following a 24-h incubation ... VK-19911 ( Pyridine, 4- [ 4- ( 4-fluorophenyl ) -1- ( 4-piperidinyl ) -1H-imidazol-5-yl ] -dihydrochloride ), a specific inhibitor of p38 alpha, prevented the induction of TNFalpha and IL-1 beta by oxidized LDL in a dose dependent manner
Smythe et al., Atherosclerosis 2003 : Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low-density lipoprotein (LDL)
Mytar et al., Inflamm Res 2004 : In MDM, intracellular TNF alpha and IL-12 expression was induced by mannan, native and modified LDL , but not other ligands
Tapiero et al., Biomed Pharmacother 2004 (Cardiovascular Diseases...) : In addition, Ox-LDL enhances the production and release of tumor necrosis factor ( TNF-alpha ), interleukin (IL)-6, arachidonic acid metabolites and nitric oxide ( NO ) that are responsible for various human pathologies including cancer
Jiang et al., Acta Pharmacol Sin 2004 : In cultured ECV304 cells, LDL or ox-LDL markedly increased the level of ADMA and TNF-alpha and potentiated the adhesion of monocytes to endothelial cells, concomitantly with a significantly decrease in the activity of DDAH and serum level of NO
Deng et al., Acta Pharmacol Sin 2004 : Aspirin inhibited the increased level of MDA and TNF-alpha induced by LDL
Blázovics et al., Orv Hetil 2004 (Inflammatory Bowel Diseases) : It became known, that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Delorme et al., Thromb Haemost 2005 (Myocardial Infarction) : They highly proliferated and were expanded in long-term culture without alterations of their phenotypic and functional properties ( Dil-ac-LDL uptake, wound repair, capillary-like network formation, and TNFalpha response )
Bartolomé et al., Ann N Y Acad Sci 2007 : Upregulation of apolipoprotein B secretion, but not lipid, by tumor necrosis factor-alpha in rat hepatocyte cultures in the absence of extracellular fatty acids
Florian et al., Steroids 2008 : Estrogen decreases TNF-alpha and oxidized LDL induced apoptosis in endothelial cells
Soares et al., Parasite Immunol 2010 (Leishmaniasis, Visceral) : LDL stimulated the production of TNF-alpha only in infected macrophages, whereas HDL stimulated the production of lower amounts of TNF-alpha in both infected and uninfected macrophages
Harada et al., Biochem Biophys Res Commun 1990 : We have investigated the effects of recombinant human tumor necrosis factor (TNF)/cachectin on the cellular binding of human low density lipoprotein (LDL) to human skin fibroblasts
Barath et al., FEBS Lett 1990 : Acetyl LDL also induced the expression of immunoreactive TNF , reaching a sevenfold maximum above control at 12 hours following a 6 hour exposure period
Wu et al., J Lipid Res 2012 (Hyperlipidemias) : Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression, inhibited the secretion of interleukin (IL)-6 and TNF-a , and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Shaik-Dasthagirisaheb et al., Molecular oral microbiology 2013 : These data indicate that LDL affects the TNF-a and IL-6 response of macrophages to P. gingivalis challenge and that MyD88 and TRIF play important roles in P. gingivalis elicited foam cell formation
Wu et al., Biochem Biophys Res Commun 2013 : The aim of this study is to evaluate the effect of simvastatin on the ox-LDL induced ER stress and expression and secretion of TNF-a and MCP-1 in 3T3-L1 adipocytes ... In conclusion, ox-LDL can stimulate the expression and secretion of TNF-a and MCP-1 through its activation of ER stress in adipocytes
Percival et al., J Am Coll Nutr 2012 (Inflammation) : Clove, ginger, rosemary, and turmeric were able to significantly reduce oxidized LDL induced expression of TNF-a
Virella et al., Clin Immunol Immunopathol 1995 : In conclusion, human macrophages are efficiently activated by LDL-IC , as reflected by the release of IL-1 beta and TNF alpha and by the release of oxygen active radicals
Maziere et al., FEBS Lett 1994 : The effect of tumor necrosis factor on the oxidative modification of LDL by U937 human monocytes or murine endothelial cells was studied by determination of the lipid peroxidation product content and the electrophoretic mobility of the particle
Stopeck et al., J Biol Chem 1993 : Tumor necrosis factor-alpha (TNF) and interleukin-1 beta (IL-1) increased LDL binding to HepG2 cells in a dose-responsive manner ... We propose that TNF and IL-1, acting via distinct signal transduction pathways, increase surface LDL receptors by increasing gene transcription
Mehran et al., Am J Physiol 1995 : De novo synthesis of apo A-I, apo B-100 , and apo B-48 was also markedly reduced by TNF-alpha
Jovinge et al., Arterioscler Thromb Vasc Biol 1996 : Human monocytes/macrophages release TNF-alpha in response to Ox-LDL ... Ox-LDL also stimulated monocyte/macrophage release of TNF-alpha in a dose dependent manner, with maximal effect at an LDL concentration of 8 micrograms/mL ... Stimulation of TNF-alpha release by Ox-LDL was associated with activation of transcription factor AP-1, whereas the activity of transcription factor nuclear factor-kB remained unchanged
Nishida et al., Am J Kidney Dis 1997 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of interleukin-6, platelet derived growth factor, and transforming growth factor-beta by mesangial cells, whereas tumor necrosis factor-alpha secretion was stimulated by oxidized LDL
Cominacini et al., J Hypertens 1997 : The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1, VCAM-1 and E-selectin induced by TNF-alpha alone or with oxidized LDL ( P < 0.001 )
González et al., Rev Med Chil 1997 (Arteriosclerosis...) : Basal and LDL stimulated tumor necrosis factor a production in vitro, by peripheral leukocytes of diabetics and controls was also measured
Netea et al., Infect Immun 1998 : Lipoprotein(a) inhibits lipopolysaccharide induced tumor necrosis factor alpha production by human mononuclear cells
Pollaud-Chérion et al., Eur J Biochem 1998 (Second Messenger Systems) : We show that lipopolysaccharide-free actetylated low-density lipoprotein (LDL) , but not native LDL, stimulates tumor-necrosis factor-alpha (TNF-alpha) secretion by rat peritoneal macrophages and the signal-transduction pathways involved ... Acetylated LDL induced Ca2+ influx and TNF-alpha production were abolished by inhibitors of phospholipase C ( U73122 ) and phospholipase A2 ( bromophenacyl bromide ), but were not affected by an inhibitor of protein kinase C ( calphostine C )
Netea et al., Cytokine 1998 : At least 4-8-h preincubation of LPS with either LDL or HDL were necessary to inhibit 50 % of the LPS induced TNF-alpha production by human peripheral blood mononuclear cells ( PBMC ), whereas after 24 h of preincubation LDL or HDL strongly inhibited the TNF-alpha synthesis ( 70-90 %, P < 0.01 )
Rovers et al., Atherosclerosis 1998 (Hyperlipoproteinemia Type II) : In addition, LDL-apheresis inhibited IL-1 and TNF production and the expression of CD11a, CD11b, CD11c and CD14 by the mononuclear cells of FH patients and this may be an additional beneficial effect of LDL-apheresis apart of decreasing LDL concentrations
Grunfeld et al., J Lipid Res 1999 : High density ( HDL ) or low density lipoprotein (LDL) alone inhibited the ability of LPS to stimulate TNF production, but had little effect on the activation by LTA