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AKT3 — TAS2R13
Text-mined interactions from Literome
He et al., J Biol Chem 2006
(Diabetes Mellitus, Experimental...) :
Role of
TRB3 in inhibition of
Akt/protein kinase B activation
Koh et al., Mol Cell Biol 2006
(Insulin Resistance) :
Akt/TRB3 binding was present in skeletal muscle, and overexpression of TRB3 in C2C12 myoblasts significantly
reduced Akt phosphorylation
Kato et al., Biochem Biophys Res Commun 2007
:
Our data indicated that the expression of TRB3 is downregulated during C2C12 cells undergoing muscle differentiation and that overexpression of
TRB3 inhibits
Akt activation during differentiation
Ding et al., Exp Cell Res 2008
:
TRB3 negatively regulates
Akt activation and noticeably,
TRB3 expression is
induced by insulin
Bi et al., Endocr J 2008
(Metabolic Syndrome X) :
The present study suggests that
TRB3 may be
involved in metabolic syndrome by inhibiting activation of
Akt in adipose tissue
Cravero et al., Arthritis Rheum 2009
(Osteoarthritis, Knee) :
TRB3 , a tribbles homolog, has been shown to
inhibit IGF-1 mediated activation of
Akt in HEK 293 cells ... Overexpression of
TRB3 inhibited
Akt phosphorylation and reduced chondrocyte survival and proteoglycan synthesis
Morse et al., Mol Immunol 2009
:
TRB3 has been shown to
inhibit the phosphorylation of
AKT/Protein Kinase B, and reduced activation of AKT has been associated with decreased cellular divisions and survival ... However in lymphocytes,
TRB3 did not
reduce the phosphorylation of
AKT , and WY14,643 treatment was associated with enhanced activation of AKT