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AKT3 — APLN

Text-mined interactions from Literome

Hashimoto et al., Int J Mol Med 2005 : Apelin induced Akt/PKB phosphorylation in APJ/293T cells, but not in the intact 293T cells ( -/293T cells )
Xie et al., Regul Pept 2006 : Apelin induced activation of Akt ( Phosphatidylinositol-3 kinase downstream effector ), but not MAPKs, such as c-jun N-terminal Kinase ( JNK ), p38 and ERK1/2 in human osteoblasts ... Furthermore, LY294002 ( PI3 kinase inhibitor ) blocked the activation of Akt by apelin and abolished the apelin induced cell proliferation
Tang et al., Peptides 2007 : Apelin activated c-Jun N-terminal kinase (JNK) and Akt ( phosphatidylinositol 3-kinase downstream effector ), and the JNK inhibitor SP600125, the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 or the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate ( HIMO ) inhibited its effects on proliferation and serum deprivation induced apoptosis
Xie et al., Apoptosis 2007 : The apelin induced activation of Akt was blocked by suppression of APJ with siRNA ... LY294002 ( a PI-3 kinase inhibitor ) or 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate ( HIMO ; an Akt inhibitor ) abolished apelin induced activation of Akt , and, LY294002 or HIMO abolished the anti-apoptotic activity of apelin
O'Donnell et al., J Neurochem 2007 : We found that ( i ) both APJ and apelin are expressed in hippocampal neurons ; ( ii ) apelin peptides induce phosphorylation of the cell survival kinases AKT and Raf/ERK-1/2 in hippocampal neurons ; and ( iii ) apelin peptides protect hippocampal neurons against NMDA receptor mediated excitotoxicity, including that induced by human immunodeficiency virus type 1
Smith et al., Cardiovasc Drugs Ther 2007 (Myocardial Ischemia...) : Basal and apelin induced phosphorylation of Akt ( at both the threonine 308 and serine 473 phosphorylation sites ) and p44/42 during the reperfusion phase was determined by Western blotting and Akt activity measured using an Enzyme Linked ImmunoSorbent Assay ( ELISA ) ... Apelin enhanced Akt and p44/42 phosphorylation at all reperfusion time points ... Akt activity did not change under basal conditions but was increased by apelin at 5 min ( NS ) and 10 min ( p < 0.05 ) reperfusion
Zeng et al., Peptides 2009 (Myocardial Reperfusion Injury) : Furthermore, apelin enhanced superoxide dismutase activity and phosphorylation of extracellular signal regulated kinase 1/2 and Akt after hypoxia/re-oxygenation
Yue et al., Am J Physiol Endocrinol Metab 2010 (Diabetes Mellitus, Type 2...) : In C2C12 myotubes, apelin increased glucose uptake and Akt phosphorylation
Cui et al., Amino Acids 2010 : Suppression of APJ with siRNA abolished the apelin induced activation of ERK and Akt ... LY294002 ( a PI3-K inhibitor ) blocked apelin induced activation of Akt and abolished the apelin induced antiapoptotic activity
Liu et al., Acta Biochim Biophys Sin (Shanghai) 2010 : Results showed that apelin-13 promoted the expression of phospho-PI3K and phospho-Akt in dose- and timedependent manner ... PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K, phospho-Akt , phospho-ERK1/2, and cyclin D1 induced by apelin-13
Li et al., Am J Physiol Heart Circ Physiol 2012 (Cardiomegaly...) : Apelin-13 also significantly increased Akt and eNOS phosphorylation and upregulated VEGF, jagged1, and notch3 expression in ischemic hearts