◀ Back to IL12A
IL12A — JAK2
Pathways - manually collected, often from reviews:
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
→
STAT4
(modification, activates)
-
BioCarta no2-dependent il-12 pathway in nk cells:
IL-12/IL-12R complex (IL12RB1-IL12RB2-IL12B_IL12A)
→
JAK2
(modification, activates)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
RIP2 (RIPK2)
(modification, activates)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
Granzyme A (GZMA)
(transcription, activates)
Salcedo et al., J Immunol 1993
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT3 (dimer)-active complex (STAT3)
(modification, activates)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
mTOR (MTOR)
(modification, activates)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
LCK (LCK)
(modification, activates)
Pignata et al., Cell Immunol 1995
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT6 (STAT6)
(modification, activates)
Moriggl et al., J Immunol 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
MIP1B (CCL4)
(transcription, activates)
Galon et al., J Immunol 1999
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(transcription, activates)
Chen et al., Nature 2000, Yoshida et al., Immunity 2001, Pflanz et al., Immunity 2002, Kamiya et al., J Immunol 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT5A (STAT5A)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
Calcineurin A alpha-beta B1 ()
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, inhibits)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
NF kappa B2 p52/RelB complex (NFKB2-RELB)
(translocation, activates)
Grohmann et al., Immunity 1998
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
HLX1 (HLX)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
Text-mined interactions from Literome
Sudarshan et al., J Immunol 1999
:
We examined this and found that TGF-beta1 did not have any effect on
IL-12 induced phosphorylation of
JAK2 , TYK2, and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
Bright et al., J Immunol 1999
(Encephalomyelitis, Autoimmune, Experimental) :
Tyrphostin B42 inhibits
IL-12 induced tyrosine phosphorylation and activation of
Janus kinase-2 and prevents experimental allergic encephalomyelitis ... Treatment of activated T cells with tyrphostin B42 inhibited the
IL-12 induced tyrosine phosphorylation and activation of
Jak-2 without affecting Tyk-2 kinase
Franchimont et al., J Immunol 2000
:
This occurred even though the level of expression of IL-12 receptors and
IL-12 induced
Janus kinase phosphorylation remained unaltered
Natarajan et al., J Immunol 2002
(Demyelinating Diseases...) :
In vitro treatment of activated T cells with curcumin inhibited
IL-12 induced tyrosine phosphorylation of
Janus kinase 2 , tyrosine kinase 2, and STAT3 and STAT4 transcription factors
Sugimoto et al., Eur J Immunol 2003
:
IL-12 activates TYK2 and
Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription ( STAT ) proteins
Muthian et al., J Clin Immunol 2004
(Disease Models, Animal...) :
In vitro treatment of activated T cells with quercetin blocks
IL-12 induced tyrosine phosphorylation of
JAK2 , TYK2, STAT3, and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Yu et al., J Immunol 2005
:
Interestingly,
IL-12 induced
activation of
Jak2 and STAT4, critical components for IL-12 mediated cellular responses, was shortened or attenuated in mutant T cells
Walker et al., Arch Virol Suppl 2005
(Ehrlichiosis) :
Ehrlichiae attach to L-selectin and E-selectin,
inhibit phagolysosomal fusion, apoptosis, and
JAK/STAT activation, and downregulate
IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Muthian et al., J Neurosci Res 2006
(Disease Models, Animal...) :
Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the
IL-12 induced tyrosine phosphorylation of
JAK2 , TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro
Shaw et al., J Immunol 2006
(Genetic Predisposition to Disease...) :
The
Jak , Tyk2, is activated in
response to
IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells
Yu et al., Biochem Pharmacol 2008
:
Like quercetin inhibits macrophage induced cytokine production, it also blocks
IL-12 dependent
JAK-STAT signaling in Th cells
Wang et al., Blood 2008
(MAP Kinase Signaling System) :
IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was
mediated by Janus kinase-signal transducers and activators of transcription (
JAK-STAT ) -dependent signaling without induction of calcium flux
Conzelmann et al., Biochem Pharmacol 2010
:
JAK2 mediated enhancing effects on
IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system ... The mechanism by which complementary
IFN-?/JAK activities
affect IL-12p70 production involves STAT1 activation and de novo induction of interferon-responsive factors (IRF)-1 and IRF-8
Bacon et al., J Exp Med 1995
:
Interleukin 12 (IL-12) induces tyrosine phosphorylation of
JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 ...
IL-12 , but not IL-2,
stimulates the tyrosine phosphorylation of TYK2 and
JAK2 , whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Yu et al., J Immunol 1996
:
Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while
IL-12 induced phosphorylation of
JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells
Gollob et al., Eur J Immunol 1997
:
One feature of Th2 differentiation in mice is the loss of
IL-12 induced
Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in response to IL-12
Bright et al., J Immunol 1998
:
TGF-beta inhibits
IL-12 induced activation of
Jak-STAT pathway in T lymphocytes
Ahn et al., J Immunol 1998
:
2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to
IL-12 induced comparable levels of
JAK2 activation and STAT5 phosphorylation