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FGF22 — INS
Text-mined interactions from Literome
Hiriart et al., Isr Med Assoc J 2001
:
Moreover, both NGF and
FGF enhance glucose induced
insulin secretion
Wente et al., Diabetes 2006
(Diabetes Mellitus, Type 2...) :
In islets isolated from diabetic rodents,
FGF-21 treatment increased islet insulin content and glucose
induced insulin secretion
Kharitonenkov et al., Endocrinology 2007
(Body Weight...) :
When administered daily for 6 wk to diabetic rhesus monkeys,
FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides,
insulin , and glucagon
Izumiya et al., FEBS Lett 2008
:
In cultured skeletal muscle cells,
FGF21 expression and secretion was
regulated by
insulin , Akt transduction and LY294002
Xu et al., Am J Physiol Endocrinol Metab 2009
(Insulin Resistance...) :
In ob/ob mice,
FGF21 led to a 40-60 % decrease in blood glucose,
insulin , and amylin levels within 1 h after injection, and the maximal effects were sustained for more than 6 h despite the 1- to 2-h half-life of FGF21 ... In DIO mice,
FGF21 reduced fasting blood glucose and
insulin levels and improved glucose tolerance and insulin sensitivity within 3 h of treatment
Vidaltamayo et al., Endocrine 1996
:
We studied the
effects of nerve growth factor (NGF),
fibroblast growth factor ( FGF ) , and dibutyryl-cAMP ( dbcAMP ) on rat pancreatic ß-cell morphology and of NGF and dbcAMP on
insulin secretion
Hamilton et al., J Cell Physiol 1985
:
Their induction is, however, correlated with the ability of the polypeptide growth factor to stimulate DNA synthesis ; EGF,
FGF , and serum
induce the SIPs, whereas insulin does not, and
insulin alone weakly stimulates DNA synthesis in these cells
Sadovnikova et al., Biull Eksp Biol Med 1988
:
The
effects of
fibroblast growth factor ( FGF ) and nerve growth factor (NGF) on DNA synthesis and
insulin secretion were studied in 4-5-day cultures of the isolated neonatal rat islets
Takeyama et al., FEBS Lett 1985
(Colonic Neoplasms) :
In Swiss 3T3 cells, colon tumor promoting deoxycholate ( DOC ) enhanced DNA synthesis which was induced by
fibroblast growth factor ( FGF ) in the
presence of
insulin ... In contrast to these bile acids, 12-O-tetradecanoylphorbol-13-acetate ( TPA ) induced DNA synthesis fully without
FGF in the
presence of
insulin ... In these cells,
FGF still induced DNA synthesis in the
presence of
insulin , but the maximal level was reduced to about one third of that in the control cells
Imamura et al., Hepatology 1996
:
In the
presence of serum and physiological concentration of
insulin ,
FGF-C ( 1211 ) by itself induces as much as 55 % of hepatocytes in culture to proliferate and up to 88 % when used in combination with hepatocyte growth factor or epidermal growth factor