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VCAM1 — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VCAM1 → VEGFA (increases)
  Evidence: VEGF may also cause an impairment of leukocyte interactions with the endothelium via the ability of endogenous NO synthesis to inhibit leukocyte rolling and adhesion and upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1

Text-mined interactions from Literome

Kikuchi et al., Nihon Rinsho Meneki Gakkai Kaishi 2000 : The current studies therefore examined the effect of bFGF and VEGF on the expression of vascular cell adhesion molecule-1 ( VCAM-1 ) on human umbilical vein endothelial cells ( HUVEC ) stimulated with tumor necrosis factor alpha (TNF-alpha) ... The data indicate that bFGF, but not VEGF , suppresses the production of VCAM-1 by HUVEC under stimulation with TNF-alpha
Kim et al., J Biol Chem 2001 : Here we examined the mechanisms underlying VEGF stimulated expression of intercellular adhesion molecule 1 ( ICAM-1 ), vascular cell adhesion molecule 1 ( VCAM-1 ), and E-selectin in human umbilical vein endothelial cells ... VEGF ( 20 ng/ml ) increased expression of ICAM-1, VCAM-1 , and E-selectin mRNAs in a time dependent manner ... VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB dependent manner ... These results suggest that VEGF stimulated expression of ICAM-1, VCAM-1 , and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase mediated suppression, but was independent of nitric oxide and MEK
Zhang et al., J Leukoc Biol 2001 : Stimulation of human umbilical vein endothelial cells by VEGF or bFGF for 18 h up-regulated intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 expression and significantly increased PMNL adhesion and TEM in response to complement fragment 5a ( C5a ) or interleukin (IL)-8
Kim et al., Circ Res 2001 : In the present study, we used human umbilical vascular endothelial cells ( HUVECs ) to examine the effect of Ang1 on VEGF induced expression of three adhesion molecules : intercellular adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin
Kim et al., Arterioscler Thromb Vasc Biol 2003 (Vasculitis) : AM inhibited the VEGF induced protein and mRNA expression of ICAM-1, VCAM-1 , and E-selectin ... Thus, AM inhibits VEGF stimulated ICAM-1 and VCAM-1 expression through a phosphatidylinositol 3'-kinase/Akt pathway
Khurana et al., Arterioscler Thromb Vasc Biol 2004 (Carotid Stenosis...) : VEGF gene transfer inhibits collar induced intimal thickening, macrophage accumulation, and VCAM-1 expression in cholesterol fed rabbits
Min et al., Circ Res 2005 : Hepatocyte growth factor suppresses vascular endothelial growth factor induced expression of endothelial ICAM-1 and VCAM-1 by inhibiting the nuclear factor-kappaB pathway
Hamada et al., Genes Dev 2005 (Neoplasms, Experimental...) : These phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of Ang-1, VCAM-1 , connexin 40, and ephrinB2 but increased expression of Ang-2, VEGF-A , VEGFR1, and VEGFR2
Chen et al., Invest Ophthalmol Vis Sci 2005 : Stimulation of hRVECs with VEGF ( 165 ), TNFalpha, or IL-1beta for 6 to 24 hours caused significant induction of intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression ... IL-1beta, TNFalpha, and VEGF ( 165 ) induced nuclear translocation and binding of p65 and p50 NF-kappaB isoforms to the VCAM-1 promoter
Lucerna et al., Blood 2007 (Carotid Artery Diseases...) : VEGF-A indeed induced a differential expression of VCAM-1 and PECAM-1 in endothelial cells
Stannard et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : VEGF alone caused no significant induction of vascular cell adhesion molecule-1 , intercellular adhesion molecule-1, or E-selectin compared with tumor necrosis factor-alpha ... In both hypercholesterolemic and normal rabbits, adenoviral VEGF-A165 expression caused no increase in endothelial vascular cell adhesion molecule-1 or E-selectin