Zheng et al., J Biol Chem 2009
:
We demonstrated that Klf4 directly binds to the 5 ' regulatory region of RAR alpha, down-regulates RAR alpha expression, and specifically inhibits RAR alpha mediated phosphatidylinositol 3-kinase (PI3K) and ERK signaling in cultured VSMCs induced by the synthetic retinoid Am80
Ghosh et al., J Biol Chem 2012
(Neurodegenerative Diseases) :
This study delineates a novel property of gemfibrozil in up-regulating SOCS3 in glial cells via PI 3-kinase-AKT mediated activation of KLF4 and suggests that gemfibrozil may find therapeutic application in neuroinflammatory and neurodegenerative disorders