Haider et al., Diabetologia 2006
(Hyperinsulinism) :
Visfatin secretion involved the phosphatidylinositol 3-kinase ( PI3-kinase ) and protein kinase B ( AKT ) pathways
Lovren et al., Am J Physiol Endocrinol Metab 2009
(Atherosclerosis...) :
Visfatin increased total Akt and Ser ( 473 ) -phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser ( 1177 ) ; these effects were blocked by LY-2940002 ... Visfatin also activated mitogen activated protein ( MAP ) kinase through PI 3-kinase, and mitogen/extracellular signal regulated kinase inhibition attenuated visfatin elicited Akt and eNOS phosphorylation
Yamawaki et al., Biochem Biophys Res Commun 2009
:
Visfatin also induced a phosphorylation of Akt at serine 473 and a substrate of cGMP dependent protein kinase, vasodilator stimulated phosphoprotein at serine 239
Oita et al., Pflugers Arch 2010
(MAP Kinase Signaling System) :
In differentiated C2C12 myoblasts, visfatin had no effects on insulin stimulated Akt phosphorylation nor on activation of the Akt signalling pathway
Jacques et al., J Biol Chem 2012
(Inflammation) :
IR was expressed in human and murine chondrocytes, and visfatin triggered Akt phosphorylation in murine chondrocytes