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ALK — BMP2

Text-mined interactions from Literome

Yao et al., Cardiovasc Res 2007 (Coronary Artery Disease) : Bone morphogenetic protein (BMP)-2 , which is known to increase condensation size, increased ALK1 expression when induced from a BMP-2 adenoviral vector
Sun et al., Biochem Biophys Res Commun 2007 (Hernia, Umbilical) : Abrogation of Alk3 mediated BMP signaling in this mouse resulted in severe defect of secondary ventral body wall formation, replicating the omphalocele phenotype in human
Hartwig et al., J Am Soc Nephrol 2008 : BMP receptor ALK3 controls collecting system development ... In summary, normal kidney development requires ALK3 dependent BMP signaling, which controls ureteric bud branching
Joziasse et al., Eur J Hum Genet 2011 (Down Syndrome...) : These data indicate that in the context of a DS background, ALK2 mediated reduction of BMP signaling may contribute to CHDs
Steinbicker et al., Blood 2011 (Iron Overload) : Both Alk2 and Alk3 were required for induction of hepcidin gene expression by BMP2 in cultured hepatocytes or by iron challenge in vivo
Kim et al., Angiogenesis 2012 (Telangiectasia, Hereditary Hemorrhagic) : Conversely, BMP9 blocks EC sprouting and this is dependent on Alk1 , BMPRII/ActRII and ID1/ID3
Somekawa et al., Proc Natl Acad Sci U S A 2012 : Among them, bone morphogenetic protein (BMP) 9 and BMP10 regulate embryonic vascular development by activating their endothelial receptor ALK1 ( activin receptor-like kinase 1, also called Acvrl1 )
Briggs et al., Circ Res 2013 (Heart Septal Defects...) : Perturbation of Alk3 mediated BMP signaling from the SHF results in impaired development of the DMP and ostium primum defects