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CREB3 — PPP2R1A
Text-mined interactions from Literome
Roach et al., Infect Immun 2005
:
Our studies are the first to demonstrate an important role for the transcription factor
CREB in TNF-alpha production by mycobacterium infected macrophages, as well as a
role for M. avium 's induction of
PP2A phosphatase activity as a mechanism to limit macrophage activation
Mauna et al., Hippocampus 2011
:
Thus, both PP1 and
PP2A regulate
CREB during LTD in area CA1, although possibly through different signaling pathways
Ferron et al., Cardiovasc Res 2011
(Calcium Signaling...) :
Aldosterone activated cAMP-response element binding protein (
CREB ), and this activation was
enhanced by blocking I ( CaT ) or by inhibiting protein
phosphatase 2A (PP2A) activity
Chung et al., J Biol Chem 2011
:
One pathway involves PKC-a catalyzed phosphorylation of
CREB and the other
involves a PKC mediated the
PP2A catalyzed dephosphorylation of Akt at Ser ( 473 ) which in turn leads to FOXO3a Ser ( 253 ) dephosphorylation and its activation
Cho et al., PloS one 2012
(Diabetes Mellitus, Type 2...) :
Importantly, overexpression of
PP2A reversed the adverse effects of chronic hyperglycemia and successfully
restored the transient activation of
CREB and ICER ... Conversely, depletion of
PP2A with siRNA was
sufficient to disrupt the negative feedback regulation of
CREB and induce hyperglycemic phenotypes even under low glucose conditions
Christen et al., Environ Sci Technol 2013
:
Phosphorylated
P-CREB , a transcription factor for PP2A,
leads to elevated expression of
PP2A