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ESR1 — JUN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
NKG2E (KLRC3)
(transcription, activates)
Levy et al., Endocrinology 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
ER alpha (ESR1)
→
JUN/FOS complex (FOS-JUN)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
ER alpha (ESR1)
→
JUN/FOS/ER alpha complex (FOS-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN/FOS complex (FOS-JUN)
→
JUN/FOS/ER alpha complex (FOS-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ER alpha (ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ATF2/JUN/ER alpha complex (ATF2-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
ER alpha (ESR1)
→
ATF2/JUN/ER alpha complex (ATF2-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
HSF2 (HSF2)
→
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
HSF2 (HSF2)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
CEBPB (CEBPB)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer)/JUN/HSF2/CEBPB complex (ESR1-JUN-HSF2-CEBPB)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
CEBPB (CEBPB)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database FOXA1 transcription factor network:
E2/ERA complex (ESR1)
→
AP1 complex (FOS-JUN)
(transcription, activates)
Eeckhoute et al., Genes Dev 2006
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer) complex (ESR1)
→
JUN (JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer) complex (ESR1)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
JUN (JUN)
→
E2/ERA (dimer)/JUN complex (ESR1-JUN)
(modification, collaborate)
Levy et al., Endocrinology 2007
Evidence: physical interaction
-
WikiPathways Integrated Breast Cancer Pathway:
ESR1
→
JUN
(mim-stimulation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
ESR1
—
JUN
(coimmunoprecipitation)
Teyssier et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
ESR1
—
JUN
(two hybrid)
Teyssier et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
ESR1
—
JUN
(affinity chromatography technology)
Teyssier et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
ESR1
—
JUN
(physical association, affinity chromatography technology)
Baron et al., J Biol Chem 2007*
-
IRef Biogrid Interaction:
ESR1
—
JUN
(direct interaction, pull down)
Teyssier et al., J Biol Chem 2001*
-
MIPS CORUM ER-alpha-GRIP1-c-Jun complex:
ER-alpha-GRIP1-c-Jun complex complex (ESR1-GRIP1-JUN)
Teyssier et al., J Biol Chem 2001*
-
MIPS CORUM ER-alpha-c-Jun complex:
ER-alpha-c-Jun complex complex (ESR1-JUN)
Teyssier et al., J Biol Chem 2001*
-
IRef Corum Interaction:
Complex of ESR1-JUN-GRIP1
(association, pull down)
Teyssier et al., J Biol Chem 2001*
-
IRef Corum Interaction:
ESR1
—
JUN
(association, pull down)
Teyssier et al., J Biol Chem 2001*
-
IRef Corum Interaction:
ESR1
—
JUN
(association, coimmunoprecipitation)
Teyssier et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Teyssier et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
ESR1
—
JUN
(in vitro)
Teyssier et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
ESR1
—
JUN
(in vivo)
Teyssier et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
ESR1
—
JUN
(aggregation, confirmational text mining)
Teyssier et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
ESR1
—
JUN
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Planas-Silva et al., Cancer Res 1999
(Breast Neoplasms) :
Other transcriptional cofactors that allow
estrogen receptor to
induce expression of
AP-1 may be required for estrogen to act as a mitogen
Walters et al., J Biol Chem 2002
:
Overexpression of the AP-1 protein
c-Jun , but not c-Fos, strongly
enhanced SKF induced
ERalpha target gene expression but only when the TRE was present
Petz et al., Endocrinology 2002
(Breast Neoplasms) :
Purified
estrogen receptor ( ER ) enhanced binding of Fos and
Jun to the +90 AP-1 site and bound to an adjacent imperfect ERE half-site
Holloway et al., Mol Endocrinol 2004
(Breast Neoplasms...) :
Despite up-regulated activator protein-1 activity in response to ERK1/2 activation, and in ERalpha ( - ) and hormone independent breast cancers, we find that increased
activator protein-1 activity is not
responsible for
ERalpha down-regulation
del Río et al., J Biol Chem 2004
:
Here we present the characterization of its mechanism of action showing that melatonin is a specific inhibitor of E ( 2 ) -induced
ERalpha mediated transcription in both estrogen response element- and
AP1 containing promoters, whereas ERbeta mediated transactivation is not inhibited or even activated at certain promoters
Dong et al., Mol Endocrinol 2007
(Breast Neoplasms) :
Moreover, it was indicated that estrogen stimulated PADI4 expression through binding of estrogen receptor (ER)-alpha to the upstream of the PADI4 gene and
ERalpha mediated
enhancement of
activator protein-1 , Sp1, and nuclear factor-Y levels
Wang et al., Cell Biol Toxicol 2010
(Adenoma...) :
In this study, we made the following observations : ( a ) 0.01 % ( v/v ) ethanol ( corresponding to 1.7 mM ) significantly elevated estrogen receptor alpha (ERalpha) protein content, stimulated
activator protein-1 (AP-1) dependent
ERalpha transcriptional activities, and ultimately enhanced GH4C1 cells growth in vitro and ( b ) the same concentration of ethanol suppressed the stimulatory effects of 17beta-estradiol ( E2 ; 10 nM ) on both cell growth and cellular PRL accumulate through attenuation of ERalpha actions at both the estrogen response element and the AP-1 site
Pedraza-Alva et al., Biochem Biophys Res Commun 2009
:
Estrogen receptor regulates MyoD gene expression by preventing
AP-1 mediated repression
Schmitt et al., J Neurosci Res 1995
:
Using transient transfections in neuroblastoma NE-1-115 and COS-1 cells, we show that ligand activated
estrogen receptor ( HEGo )
represses the transcriptional activation by
c-Fos/c-Jun