Sekar et al., Am J Physiol Endocrinol Metab 2004
:
Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells ... Mithramycin, an inhibitor of Sp1/Sp3 protein ( s ) binding, blocked hormonally induced LDLR promoter expression by 80 %
Sanchez et al., J Biol Chem 1995
:
Regulation of the low density lipoprotein (LDL) receptor promoter by cholesterol requires a well defined sterol regulatory site and an adjacent binding site for the universal transcription factor Sp1