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EGFR — IGFBP3
Text-mined interactions from Literome
Takaoka et al., Am J Physiol Gastrointest Liver Physiol 2006
:
However, unlike other cell types where IGFBP-3 exerts antiproliferative effects, neither wild-type nor GGG mutant
IGFBP-3 alone
affected cell proliferation or
EGFR activity
Martin et al., J Biol Chem 2009
:
SphK1 expression and activity were
stimulated by
IGFBP-3 approximately 2-fold over 24 h. Silencing of sphingosine 1-phosphate receptor 1 ( S1P1 ) or S1P3, but not S1P2, abolished the effect of IGFBP-3 on EGF stimulated
EGFR activation ... These data indicate that potentiation of growth factor signaling by IGFBP-3 in MCF-10A cells requires SphK1 activity and S1P1/S1P3, suggesting that S1P, the product of SphK activity and ligand for S1P1 and S1P3, is the `` missing link ''
mediating IGF and
EGFR transactivation and cell growth stimulation by
IGFBP-3
McIntosh et al., J Biol Chem 2010
(Breast Neoplasms...) :
Although
IGFBP-3 did not
affect EGFR phosphorylation [ Tyr ( 1068 ) ], it was found to modulate receptor internalization and was associated with activation of Rho and subsequent changes in MAPK phosphorylation