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CDKN1A — ERBB2

Text-mined interactions from Literome

Tan et al., Mol Cell 2002 (Breast Neoplasms) : One mechanism is via ErbB2 mediated upregulation of p21 ( Cip1 ), which inhibits Cdc2
Lee et al., Cancer Res 2002 (Breast Neoplasms) : Thus, Herceptin treatment of ErbB2 overexpressing cells can inhibit ErbB2 mediated Cdc2-Tyr-15 phosphorylation and p21 ( Cip1 ) up-regulation, which allows effective p34 ( Cdc2 ) activation and induction of apoptosis upon Taxol treatment
Yu et al., Mol Cell 1998 (Breast Neoplasms) : Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1 , which associates with p34Cdc2, inhibits Taxol mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol induced apoptosis