Nakashima et al., J Pharmacol Exp Ther 2010
(Carcinoma, Non-Small-Cell Lung...) :
Ectopic expression of wild-type PRL-1 increased RhoA levels, which have an important role in actin filament assembly and stabilization of focal adhesion, and decreased activated Cdc42 and Rac
Bai et al., J Biol Chem 2011
:
Furthermore, PRL-1 binding activates RhoA signaling by inhibiting the catalytic activity of p115 RhoGAP