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SLC22A3 — WNT4
Text-mined interactions from Literome
Taki et al., Cancer Sci 2003
(Carcinoma, Squamous Cell...) :
To study whether the expressions of these
Wnt genes are
regulated by
EMT , we transfected a Snail-expression vector into A431 and OM-1 cells, which express Wnt-4 but not Wnt-5a ... These results indicated that
Wnt-4 and Wnt-5a are oppositely
affected by
EMT , and down-regulation of Wnt-4 and up-regulation of Wnt-5a are possible markers of the malignant phenotype of human SCC
Nawshad et al., Cells Tissues Organs 2005
(MAP Kinase Signaling System...) :
Early studies of the developing embryo have designated the
involvement of
Wnt signaling in
EMT , through an activated complex of the lymphoid enhancing factor-1 (LEF-1) transcription factor and the cell adhesion molecule beta-catenin
Moustakas et al., Cancer Sci 2007
(Cell Transformation, Neoplastic...) :
Transforming growth factor-beta,
Wnt , Notch and growth factors acting through tyrosine kinase receptors
induce EMT and often act in a sequential manner
Chong et al., Exp Eye Res 2009
(Cataract) :
Given that
Wnt signaling is
involved in TGFbeta induced
EMT in other systems, this study set out to determine if Wnt signaling has a role in regulating this process in the lens ... Overall, the results from the current study indicate that
Wnt signaling is
involved in TGFbeta induced
EMT and development of fibrotic plaques in the lens
Katoh et al., Curr Pharm Biotechnol 2011
:
Because FGF, Hedgehog, TGFß, and non-canonical
WNT signals synergistically
induce EMT regulators, such as Snail ( SNAI1 ), Slug ( SNAI2 ), TWIST, and ZEB2 ( SIP1 ), tumor-stromal interaction at the invasion front aids cancer stem cells to acquire more malignant phenotype
Emmett et al., Stem Cells Dev 2012
(Wnt Signaling Pathway) :
These results suggest that in addition to patterning the early embryo, Geminin
plays a previously unrecognized role in
EMT via its ability to affect
Wnt signaling and E-cadherin expression
Dunlap et al., Cancer prevention research (Philadelphia, Pa.) 2012
(Carcinoma, Basal Cell...) :
Conversely, CR suppressed
M-Wnt and E-Wnt tumor progression ( P < 0.02, each ) and
inhibited EMT and intratumoral adipocyte accumulation
Zhang et al., Carcinogenesis 2013
(Carcinoma, Hepatocellular...) :
Our results suggest that
Wnt/ß-catenin signaling
enhances hypoxia induced
EMT in HCC by increasing the EMT associated activity of hif-1a and preventing tumor cell death
Wang et al., Pathol Oncol Res 2013
:
Overexpression of galectin-3 promoted Tca8113 cell proliferation, migration and invasion, upregulated
Wnt protein expression, activated ß-catenin and
induced the
EMT ; knockdown of galectin-3 had the opposite effects
Kanzawa et al., Pathobiology 2013
:
Conclusions
: WNT5A regulates the induction of
EMT and the maintenance of CSC properties in MKN-7 cells