◀ Back to MYC
MYC — NOTCH1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
NOTCH1
→
MYC
(transcriptional regulation, increase)
Hsu et al., Mol Cell Biol 2008
Evidence: PROMACTIVITY, DNABINDING
-
FastForward regulation:
YY1, NOTCH1
→
MYC
(transcriptional regulation, increase)
Hsu et al., Mol Cell Biol 2008
Evidence: PROMACTIVITY, DNABINDING
-
NCI Pathway Database Notch signaling pathway:
NICD/YY1 complex (YY1-NOTCH1)
→
MYC (MYC)
(transcription, activates)
Satoh et al., J Biol Chem 2004*, Weng et al., Genes Dev 2006*, Palomero et al., Proc Natl Acad Sci U S A 2006*, Liao et al., Carcinogenesis 2007*, Hsu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Rao et al., Mol Cell Biol 2003
:
c-Myc expression was also maintained in low serum, indicating that
Notch 's
effects on
c-Myc are not specific to TGF-beta
Palomero et al., Proc Natl Acad Sci U S A 2006
(Leukemia) :
NOTCH1 directly
regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth ... By integrating gene expression array and ChIP-on-chip data, we show that
NOTCH1 directly activates multiple biosynthetic routes and
induces c-MYC gene expression
Riz et al., Molecular cancer 2010
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
We found that TLX1 and
NOTCH synergistically
regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of
MYC
Li et al., J Exp Med 2011
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
miR-451 but not miR-709 is conserved in humans, and human T-ALLs with activating NOTCH1 mutations have decreased miR-451 and
increased MYC levels compared with T-ALLs with wild-type
NOTCH1
Blackburn et al., Leukemia 2012
(Cell Transformation, Neoplastic...) :
Here, we utilized a zebrafish transgenic model of T-ALL, where
Notch does not
induce Myc transcription, to identify a novel Notch gene expression signature that is also found in human T-ALL and is regulated independently of Myc