Gene interactions and pathways from curated databases and text-mining

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MYC — NOTCH1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Rao et al., Mol Cell Biol 2003 : c-Myc expression was also maintained in low serum, indicating that Notch 's effects on c-Myc are not specific to TGF-beta
Palomero et al., Proc Natl Acad Sci U S A 2006 (Leukemia) : NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth ... By integrating gene expression array and ChIP-on-chip data, we show that NOTCH1 directly activates multiple biosynthetic routes and induces c-MYC gene expression
Riz et al., Molecular cancer 2010 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : We found that TLX1 and NOTCH synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC
Li et al., J Exp Med 2011 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : miR-451 but not miR-709 is conserved in humans, and human T-ALLs with activating NOTCH1 mutations have decreased miR-451 and increased MYC levels compared with T-ALLs with wild-type NOTCH1
Blackburn et al., Leukemia 2012 (Cell Transformation, Neoplastic...) : Here, we utilized a zebrafish transgenic model of T-ALL, where Notch does not induce Myc transcription, to identify a novel Notch gene expression signature that is also found in human T-ALL and is regulated independently of Myc