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CDK2 — CDT1

Pathways - manually collected, often from reviews:

• BioCarta cdk regulation of dna replication: Cyclin E/CDK2/p27 complex (CCNE1-CDK2-CDKN1B) → ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: Cyclin E/CDK2/p27 complex (CCNE1-CDK2-CDKN1B) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) (regulation of DNA replication initiation, activates)
  
• Reactome Reaction: CDT1 → CDK2 (reaction) Méndez et al., Mol Cell 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDT1 — CDK2 (physical association, affinity chromatography technology) Sugimoto et al., J Biol Chem 2004
• IRef Biogrid Interaction: CDT1 — CDK2 (direct interaction, pull down) Sugimoto et al., J Biol Chem 2004
• IRef Biogrid Interaction: CDT1 — CDK2 (direct interaction, enzymatic study) Takeda et al., J Biol Chem 2005*
• IRef Biogrid Interaction: CDT1 — CDK2 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: CDT1 — CDK2 (physical association, affinity chromatography technology) Liu et al., J Biol Chem 2004*
• IRef Hprd Interaction: CDT1 — CDK2 (in vitro) Sugimoto et al., J Biol Chem 2004
• IRef Hprd Interaction: CDT1 — CDK2 (in vivo) Sugimoto et al., J Biol Chem 2004
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of SKP2-CCNA1-CDK2-CCNA2-CDK1-CDT1 (association, coimmunoprecipitation) Sugimoto et al., J Biol Chem 2004

Text-mined interactions from Literome

Sugimoto et al., J Biol Chem 2004 : Cdk phosphorylation resulted in the binding of Cdt1 to the F-box protein Skp2 and subsequent degradation
Liu et al., J Biol Chem 2004 : Overexpression of cyclin dependent kinase inhibitors such as p21 and p27 dramatically suppresses the phosphorylation of Cdt1, disrupts the interaction of Cdt1 with the F-box protein Skp2, and blocks the degradation of Cdt1 ... These data suggest that cyclin/Cdk mediated Cdt1 phosphorylation is required for the association of Cdt1 with the SCF ( Skp2 ) ubiquitin ligase and thus is important for the cell cycle dependent degradation of Cdt1 in mammalian cells