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AKT2 — GNRH2
Text-mined interactions from Literome
Mutiara et al., Mol Cell Endocrinol 2008
:
Using the well differentiated, clonal gonadotroph cell line, LbetaT2, we examined ( 1 ) whether
Akt/PKB was
activated by gonadotropin releasing hormone
(GnRH) ; ( 2 ) the contribution of PI3-kinase-Akt/PKB pathway in each of gonadotropin subunit gene expression ; ( 3 ) crosstalk between extracellular signal regulated kinase ( ERK ) and Akt/PKB pathways
Zhao et al., Zhonghua Fu Chan Ke Za Zhi 2009
(Endometrial Neoplasms) :
Triptorelin and
GnRH-II inhibited the
Akt and ERK1/2 activity in the endometrial carcinoma cells
Ling Poon et al., Endocrinology 2011
(Ovarian Neoplasms) :
In our studies of OVCAR-3 and CaOV-3 ovarian cancer cell lines,
GnRH-II treatment
induced phosphorylation of
Akt and glycogen synthase kinase ( GSK ) 3ß, as well as ß-catenin accumulation in the nucleus, and the latter was reduced by small interfering RNA ( siRNA ) -mediated depletion of the GnRH receptor