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AKT2 — ANG

Text-mined interactions from Literome

Takahashi et al., Am J Physiol 1999 : Stimulation of the cells with ANG II led to a marked increase in the kinase activity of Akt/PKB , which coincided with Ser-473 phosphorylation
Kim et al., Circ Res 2000 : Ang1 induced phosphorylation of the serine-threonine kinase Akt at Ser473 in a PI 3'-kinase dependent manner
Kim et al., Oncogene 2000 : Accordingly, 800 ng/ml of Ang2 induced phosphorylation of Tie2, the p85 subunit of phosphatidylinositol 3'-kinase ( PI 3'-kinase ), and serine-threonine kinase Akt at Ser473 in the human umbilical vein endothelial cells ; lower concentrations of Ang2 ( 50 - 400 ng/ml ) did not produce notable effects
Gorin et al., FASEB J 2001 : Ang II causes rapid activation of Akt/PKB ( 5-10 min ) but delayed activation of phosphoinositide 3-kinase (PI3-K) ( 30 min )
Lee et al., FASEB J 2004 (Corneal Neovascularization) : Ang4 ( 400 ng/mL ) markedly increased Tie2 and Akt phosphorylation in primary cultured HUVECs whereas Ang3 ( 400 ng/mL ) did not produce significant changes
Haider et al., Mol Pharmacol 2005 : Our group has shown previously that RV inhibits angiotensin II (Ang II) induced Akt activation and, consequently, vascular smooth muscle cell ( VSMC ) hypertrophy
Murakami et al., J Biol Chem 2005 : These data suggested that Ang1 dependent Akt phosphorylation through PI 3-kinase leads to the inhibition of JNK phosphorylation
Li et al., Am J Physiol Heart Circ Physiol 2005 (Carotid Artery Injuries) : In cultured vascular smooth muscle cells, ANG II activates Akt through cytosolic phospholipase A2 (cPLA2) dependent phospholipase D2 (PLD2)
Tsigkos et al., J Cell Physiol 2006 : Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells ... Inhibition of PI3-kinase with wortmannin led to a stimulation of basal Ang2 release in EC, while overexpression of an active form of Akt reduced Ang2
Hingtgen et al., Physiol Genomics 2006 (Hypertrophy) : Finally, ANG II caused a time dependent increase in Akt activity via activation of AT(1) receptors, and this response was abolished by Ad-mediated expression of cytosolic human O2-* dismutase ( AdCu/ZnSOD )
Kim et al., J Am Soc Nephrol 2006 (Fibrosis...) : COMP-Ang1 increased Tie2 and Akt phosphorylation in ureteral obstructed kidneys
Block et al., Antioxid Redox Signal 2006 : Ang II causes activation of Akt/PKB and induces fibronectin protein expression, effects abrogated by phospholipase A ( 2 ) inhibition and mimicked by AA
Kim et al., Biochem Biophys Res Commun 2007 : Angiogenin induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells
Imanishi et al., Cancer Res 2007 (Breast Neoplasms...) : Using a xenograft model, we show that overexpression of Ang2 in poorly metastatic MCF-7 breast cancer cells suppresses expression of E-cadherin and induces Snail expression and phosphorylation of Akt and glycogen synthase kinase-3beta ( GSK-3beta ) promoting metastasis to the lymph nodes and lung
Giani et al., Am J Physiol Heart Circ Physiol 2007 : In contrast to ANG II, ANG- ( 1-7 ) stimulated cardiac Akt phosphorylation, and this stimulation was blunted in presence of the receptor Mas antagonist A-779 or the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin ... The specific JAK2 inhibitor AG-490 blocked ANG- ( 1-7 ) -induced JAK2 and IRS-1 phosphorylation but had no effect on ANG- ( 1-7 ) -induced phosphorylation of Akt, indicating that activation of cardiac Akt by ANG- ( 1-7 ) appears not to involve the recruitment of JAK2 but proceeds through the receptor Mas and involves PI3K
Yuan et al., FASEB J 2007 : Ang1 mediated AKT and 42/44MAPK phosphorylation is predominantly Tie2 mediated, and Tie1 down-regulates this pathway
Liu et al., Acta Pharmacol Sin 2008 (Anoxia) : Ang1 induced Akt phosphorylation, increased the Bcl-2/Bax ratio, and decreased the activation of caspase-9 and -3
White et al., Angiogenesis 2008 : ANG9-4 blocked Ang1 mediated Tie2 phosphorylation and downstream Akt activation
Yuan et al., Mol Cell Biol 2009 : However, when ECs are stimulated with Ang1 and Ang2, Ang2 dose-dependently inhibits Ang1 induced Tie2 phosphorylation, Akt activation, and EC survival
Katoh et al., Exp Cell Res 2009 : Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited Ang1 induced Akt phosphorylation, but not Erk1/2 phosphorylation
Arellano-Plancarte et al., Biochem Pharmacol 2010 (Insulin Resistance) : To investigate the potential interactions between the angiotensin II (Ang II) and insulin signaling systems, regulation of IRS-1 phosphorylation and insulin induced Akt activation by Ang II were examined in clone 9 ( C9 ) hepatocytes
Singh et al., Microvasc Res 2010 : Examination of downstream signaling revealed inhibition of Ang1 dependent Akt phosphorylation ... Similar suppression of Ang1 dependent activation of Akt by hyperglycemia was observed in large vessel human endothelial cells ... Incubation of microvascular endothelial cells with 200 microM palmitic acid significantly inhibited Ang1 dependent Akt phosphorylation without affecting phosphorylation of the Tie-2 receptor or of ERK1/2
Muñoz et al., Regul Pept 2010 : Thus, in the present study, we evaluated the ability of ANG- ( 1-7 ) to stimulate the phosphorylation of Akt , a main mediator of insulin action in rat extracardiac tissues ( adipose tissue, liver and skeletal muscle )
Csibi et al., PloS one 2010 : Inhibition of nitric oxide synthase and NAD ( P ) Hoxidase and scavenging of free radicals with myricetin restored insulin stimulated Akt phosphorylation and GLUT4 translocation in the presence of Ang II
Zhao et al., Ethn Dis 2010 (Cardiomegaly) : This was also relevant to I ( K ) functional density which was reduced by activation of both MAPKs and Akt by angiotensin II (ANG II) and insulin-like growth factor-1 (IGF-1), respectively ; however, this reduction was reversed by inhibition of PI-3K alone in hypertrophied myocytes but not in normal ones
Schreiner et al., Cardiovasc Res 2011 : Resveratrol ( RV ), an antioxidant, inhibits angiotensin II (Ang II) induced hypertrophy and Ang II- or epidermal growth factor (EGF) induced Akt phosphorylation in rat vascular smooth muscle cells ( VSMCs )
Lopez Verrilli et al., J Neurochem 2012 : Ang- ( 1-7 ) through Mas receptors stimulated Akt and ERK1/2 activities in spontaneously hypertensive rat neurons
Steidinger et al., PloS one 2013 (Disease Models, Animal...) : Angiogenin in Parkinson Disease Models : Role of Akt Phosphorylation and Evaluation of AAV Mediated Angiogenin Expression in MPTP Treated Mice