◀ Back to EPHB2

EPHB2 — RPS6KA1

Text-mined interactions from Literome

Richards et al., Curr Biol 1999 : Nevertheless, activation of full-length RSK1 in the absence of serum required activation by both PDK1 and ERK ... Activation of phosphotransferase activity of full-length RSK1 in vivo requires both PDK1 and ERK
Chen et al., Bioorg Med Chem Lett 2006 : Of the 13 compounds tested, 4 compounds strongly inhibited ERK mediated phosphorylation of ribosomal S6 kinase-1 (Rsk-1) and/or the transcription factor Elk-1 and inhibited the proliferation of HeLa cervical carcinoma cells with IC ( 50 ) values in the 2-10 microM range
Jozwiak et al., Neuromolecular Med 2007 (Angiomyolipoma...) : Here, we show for the first time that in all four brain lesions and one angiomyolipoma from TS patients both extracellular signal regulated kinase ( Erk ) and p90 ribosomal S6 kinase 1 activation as well as Erk dependent phosphorylation of p70 ribosomal S6 kinase 1 are markedly elevated whereas Akt, participating in the classical pathway of mammalian target of rapamycin activation is not always activated
Kharebava et al., J Neurosci 2008 : Consistent with the observations that in BDNF stimulated neurons RSK1/2 activation required both PDK1 and ERK1/2 , ERK1/2 knockdown removed BDNF mediated survival